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TranscriptomicsRAP1 protects from obesity, diabetes and metabolic syndrome through its extra telomeric role regulating gene expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-43174 | biostudies-arrayexpress
GenomicsGenome-wide maps of RAP1 binding sites.
By performing chromatin immunoprecipitation coupled with ultra-high-throughput sequencing (ChIP-seq), we find that RAP1 binds to telomeres as well as to extra-telomeric sites through the (TTAGGG)2 consensus motif. Extra-telomeric RAP1 binding sites are particularly abundant at subtelomeric regions, ...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-20867 | biostudies-arrayexpress
TranscriptomicsRAP1 protects from obesity, diabetes and metabolic syndrome through its extra telomeric role regulating gene expression (old mouse liver)
RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres. Unlike other shelterins, however, RAP1 is not essential for preventing telomere fusions. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the non-te...
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-43173 | biostudies-arrayexpress
TranscriptomicsRAP1 protects from obesity, diabetes and metabolic syndrome through its extra telomeric role regulating gene expression (young mouse liver)
RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres. Unlike other shelterins, however, RAP1 is not essential for preventing telomere fusions. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the non-te...
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-43171 | biostudies-arrayexpress
TranscriptomicsRAP1 protects from obesity, diabetes and metabolic syndrome through its extra telomeric role regulating gene expression (young mouse white fat)
RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres. Unlike other shelterins, however, RAP1 is not essential for preventing telomere fusions. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the non-te...
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-43172 | biostudies-arrayexpress
TranscriptomicsRoles of mammalian Rap1 in TERT recruitment to chromatin, subtelomeric gene silencing and transcriptional regulation
Repressor-activator protein 1 (scRap1) is the major binding activity at Saccharomyces cerevisiae telomeres, with roles in telomere length regulation and establishment of subtelomeric silencing by recruiting the Sir proteins. scRap1 also acts as a transcription factor controlling the expression of ri...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-19011 | biostudies-arrayexpress
UnknownShorter telomere length and suicidal ideation in familial bipolar disorder.
Not available
S-EPMC9721487 | biostudies-literature
UnknownLaterality and Completeness Patterns of Nonsyndromic Clefts in a Multiethnic Cohort.
Not available
S-EPMC12772681 | biostudies-literature
UnknownClinical Characteristics Associated with the PLP-PLS Index, a New Potential Metric to Phenotype Phantom Limb Pain.
Not available
S-EPMC11429012 | biostudies-literature
UnknownCortistatin as a Novel Multimodal Therapy for the Treatment of Parkinson's Disease.
Not available
S-EPMC10815070 | biostudies-literature
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