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MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
MetabolomicsRapid UHPLC-MS metabolite profiling and phenotypic assays reveal genotypic impacts of nitrogen supplementation in oats
INTRODUCTION: Oats (Avena sativa L.) are a whole grain cereal recognised for their health benefits and which are cultivated largely in temperate regions providing both a source of food for humans and animals, as well as being used in cosmetics and as a potential treatment for a number of...
2020-06-11 | MTBLS804 | MetaboLights
UnknownTherapy with stem cells in inflammatory bowel disease.
Not available
S-EPMC3921504 | biostudies-literature
Unknown4-Methylumbelliferone Modulates CAIX to Mitigate Hypoxia-Driven Dysregulation and Enhance PD-1 Immunotherapy in Lung Cancer.
Not available
S-EPMC12610671 | biostudies-literature
UnknownHepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients.
Not available
S-EPMC10573696 | biostudies-literature
TranscriptomicsTranscription profiling by microarray of barley mutant (G132) and its wild type (Hordeum vulgare cv. Graphic) under high CO2 concentration
This experiment showed the microarray expression of a barley recessive mutant (G132) and its wild type (Hordeum vulgare cv. Graphic) under high CO2 concentration. The homozygous mutation has a strong pleiotropic nature affecting many aspects of plant. In order to identify target genes of this mutati...
ORGANISM(S): Hordeum vulgare 
2017-02-07 | E-MTAB-4942 | biostudies-arrayexpress
UnknownAdvancing Environmental Justice in the Community Using Charrette: A Case Study in Boston Chinatown
Not available
S-EPMC10704576 | biostudies-literature
MetabolomicsAssessing the impact of nitrogen supplementation in oats across multiple growth locations and years with targeted phenotyping and high-resolution metabolite profiling approaches
Oats (Avena sativa L.) are a healthy food, being high in dietary fibre (e.g. β-glucans), antioxidants, minerals, and vitamins. Understanding the effect of variety and crop management on nutritional quality is important. The response of four oat varieties to increased nitrogen levels was investigated...
2021-04-26 | MTBLS1801 | MetaboLights
ProteomicsNeddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally down-regulated protein 8, to target proteins, with yet-unknown consequences. Here we show in mice that neddylation in liver is modulated by nutrient availability. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-08 | PXD043054 | Pride
Pck1 Neddylation Glucose 
UnknownDevelopment and Implementation of a Safety Incident Report System for Health Care Discipline Students During Clinical Internships: Observational Study.
Not available
S-EPMC11294782 | biostudies-literature
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