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TranscriptomicsLenses expression profile of DBL oncogene transgenic mice
The Dbl family of proteins represents a large group of proto-oncogenes involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental disorders and neoplastic transformation. We have generated transgenic mice introducing ...
ORGANISM(S): Mus musculus 
2009-06-01 | E-GEOD-15694 | biostudies-arrayexpress
MetabolomicsLysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity

Lysosomes are key cellular organelles that metabolize extra- and intra-cellular substrates. Alterations in lysosomal metabolism are implicated in aging-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to ...

2022-05-06 | MTBLS4654 | MetaboLights
TranscriptomicsRNA-seq of immortalized rat thyrocytes (PCCl3) treated with two thyroid disrupting chemicals (ethylenethiourea and chlorpyrifos) against untreated controls
The transcriptomic dose-dependent response of rat immortalized thyrocytes to two thyroid disrupting chemicals was investigated by RNA-seq experiment. PCCl3 cells were exposed for one week to different doses of ethylenethiourea (ETU) and chlorpyrifos (CPF) and to their combinations.
ORGANISM(S): Rattus norvegicus 
2016-12-06 | E-MTAB-5269 | biostudies-arrayexpress
TranscriptomicsIn vitro and in vivo evidences of osteocytes involvement in myeloma-induced osteoclast formation and bone disease
The involvement of osteocytes in multiple myeloma (MM)-induced osteoclast formation and the occurrence of bone lesions are still unknown. Osteocytes regulate bone remodeling at least in part through the cell death and apoptosis triggering osteoclast recruitment and formation. In this study, firstly ...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-27372 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human circulating endothelial cells before and after Iloprost infusion in patients with progressive Systemic sclerosis.
Gene expression profiling in circulating endothelial cells before and after Iloprost infusion in patients with progressive Systemic sclerosis.
ORGANISM(S): Homo sapiens 
2010-06-28 | E-MEXP-2769 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of endothelial cells and dermal fibroblasts treated with anti-HCMV antibodies to induce modifications typical of scleroderma phenotype
Both human endothelial cells and dermal fibroblasts have been treated with anti-HCMV antibodies to induce modifications typical of scleroderma phenotype.
ORGANISM(S): Homo sapiens 
2005-08-01 | E-MEXP-382 | biostudies-arrayexpress
ProteomicspiRNA-guided co-transcriptional silencing coopts nuclear export factors
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal germlines1,2. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptional repression of transposons by Piwi. This de...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-20 | PXD011415 | Pride
Pirna transposons piwi nuclear export 
UnknownClinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.
Not available
S-EPMC6075859 | biostudies-literature
TranscriptomicsGene expression profile in melanomas from Pdk1-inactivated BrafV600E::Pten-/- mice
Gene expression profiling was performed to access the changes in gene expression in melanomas from Pdk1-inactivated Brafv600E::Pten-/- mice. The expression profiles of the BrafV600E::Pten-/-::Pdk1-/- were compared to the BrafV600E::Pten-/-::Pdk+/+ genotypes. The analysis has identified several imp...
ORGANISM(S): Mus musculus 
2013-09-17 | E-GEOD-42187 | biostudies-arrayexpress
ProteomicsRequirement of Nuclear Pore Complex Subunits for transposon silencing in Drosophila
The piRNA pathway is a small RNA-based immune system that silences mobile genetic elements in animal germlines. In Drosophila ovaries, piRNAs are produced from discrete genomic loci, called piRNA clusters, which are composed of inactive transposon copies and fragments and thus constitute a genetical...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-15 | PXD019670 | Pride
Pirna piwi npc nuclear export 
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