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MetabolomicsAn integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients

INTRODUCTION: The identification of frequent acquired mutations shows that patients with oligodendrogliomas have divergent biology with differing prognoses regardless of histological classification. A better understanding of molecular features as well as their metabolic pathways...

2021-10-06 | MTBLS869 | MetaboLights
TranscriptomicsTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Identification of gene expression patterns that correlate with distinct stages of male germ cell development using biopsies from men with highly defined and homogenous testicular pathologies based on the Johnsen score procedure. The Johnsen score procedure is a classical histopathological scoring pr...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-234 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cells treated with Bacillus anthracis lethal toxin (LT)-intoxicated HUVECs monolayers
We have analyzed the variation of transcriptome of HUVECs intoxicated by the lethal toxin of Bacillus anthracis at 4 and 8 hours Experiment Overall Design: Three experimental conditions with two biological replicates for the control condition corresponding to untreated HUVEC monolayer. RNA were extr...
ORGANISM(S): Homo sapiens 
2010-01-29 | E-GEOD-12131 | biostudies-arrayexpress
TranscriptomicsExpression data from pregnant rat hearts
Hyperhomocysteinemia (HHcy) causes cardiovascular dysfunction and is associated with many complications during pregnancy related to reduced NO bioactivity. The mechanisms of HHcy on the NO-dependent control of myocardial metabolism was compared with L-NAME, which directly inhibits NO bioavailability...
ORGANISM(S): Rattus norvegicus 
2015-06-12 | E-GEOD-30308 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of brain from zebrafish treated with ethanol or nicotine suggests conservation of neuro-adaptation pathways
Effect of ethanol or nicotine exposure on gene expression compared to control. Duplicate arrays from ethanol or nicotine treated animals compared with triplicate arrays from paired control animals. In total 4 treatment arrays (2 ethanol, 2 nicotine) and 3 control arrays (from control animals treate...
ORGANISM(S): Danio rerio 
2008-05-01 | E-MEXP-1301 | biostudies-arrayexpress
TranscriptomicsGenome wide transcriptional oscillation for Saccharomyces cerevisiae CEN.PK122
Genetic and environmental stresses are known factors that influence an organisms phenotype. Time is rarely taken into consideration when studying phenotypic changes in cells. Time-resolved microarray data revealed genome-wide transcriptional changes in yeast strain CEN.PK122 oscillating with~2 perio...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-16 | E-GEOD-30054 | biostudies-arrayexpress
TranscriptomicsSpecific extracellular matrix remodeling signature of colon hepatic metastases [HG-U133B]
To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. W...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-62321 | biostudies-arrayexpress
TranscriptomicsA compendium of antibiotic-induced transcription profiles reveals broad regulation of P. multocida virulence genes
Treatment of bacteria with antibiotics at or close to the inhibitory concentration leads to specific transcriptional responses often affecting target genes and targets pathways. A dataset of transcriptional profiles (compendium) induced by antibiotics with known mode-of-action (MoA) can be used to g...
ORGANISM(S): Pasteurella multocida 
2008-06-01 | E-GEOD-10051 | biostudies-arrayexpress
TranscriptomicsOxidant-NO-dependent gene regulation in dogs with type I diabetes
The global changes in cardiac gene expression in dogs with alloxan-induced diabetes were studied using Affymetrix Canine Array. Cardiac RNA was extracted from the control and DM (n=4). The array data revealed that 797 genes were differentially expressed (P<0.01; fold change of at least ±2). 150 gene...
ORGANISM(S): Canis lupus familiaris 
2010-08-23 | E-GEOD-14887 | biostudies-arrayexpress
TranscriptomicsDynamics of two oscillation phenotypes in S. cerevisiae [2hr]
Genetic and environmental factors influence the phenotype of an organism. Time is rarely considered when studying changes in cellular phenotype. Time-resolved microarray data revealed genome-wide transcriptional changes in cells oscillating with ~2 and ~4 h periods. We mapped the global patterns of ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-16 | E-GEOD-30051 | biostudies-arrayexpress
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