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ModelsPanRTK model for single cell line
Hass2017-PanRTK model for single cell line The model structure comprises heterodimerization and receptor trafficking as described in detail in the article below. For ligand input, set a respective event. The illustrated event sets the EGF concentration to 2.5 nMol in the model file. This model is...
MODEL1708210000 | BioModels
ProteomicsSingle-shot proteome of AML cell lines and AML ex vivo cells upon selinexor treatment
Single-shot proteome analysis of 4 AML cell lines; 2 selinexor sensitive cell lines (GDM-1, MV4-11) and 2 resistant cell lines (NOMO-1 and PL-21) and ex vivo AML cells from 30 patients treated with DMSO (B; before treatment) or 1 uM selinexor (A; after treatment) for 6 hours.
ORGANISM(S): Homo sapiens (Human) 
2022-08-07 | PXD033515 | Pride
Human Lc-msms Aml 
ProteomicsSpatial proteomics of selinexor, MK-2206 and combination response in AML cells
In order to characterize the dynamics of proteins between different cellular compartments in response to selinexor (XPO1 inhibitor), MK-2206 (Akt inhibitor) an the combination i AML cells, we treated MV4-11 and PL-21 cells for 6 hours with DMSO, 1 uM selinexor, 1 uM MK-2206 or the combination. Each...
ORGANISM(S): Homo sapiens (Human) 
2022-08-07 | PXD033527 | Pride
Human Spatial proteomics Aml Lc-ms/ms 
ProteomicsPhosphoproteomics analysis of Selinexor response in AML ex vivo patient samples and cell lines
We used mass spectrometry-based proteomics to perform a phosphoproteomics analysis of selinexor-treated ex vivo AML patient samples (n=20) and 4 AML cell lines (PL-21, NOMO-1, GDM-1 and MV4-11). For quantitative phosphoproteomics, we used a tandem mass tag (TMT)-based approach. Conditions for the TM...
ORGANISM(S): Homo sapiens (Human) 
2022-08-07 | PXD017660 | Pride
Lc-msms Selinexor Human Aml 
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