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TranscriptomicsMaternal Western-style high fat diet induces sex-specific physiological and molecular changes in two-week-old mouse offspring
Maternal diet is associated with the development of metabolism-related and other non-communicable diseases in offspring. Underlying mechanisms, functional profiles, and molecular markers are only starting to be revealed. Here, we explored the physiological and molecular impact of maternal Western-st...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-46359 | biostudies-arrayexpress
ProteomicsAre you also what Your Mother Eats? Distinct Proteomic Portrait as a Result of Maternal High-Fat Diet in the Cerebral Cortex of the Adult Mouse.
Background: Epidemiological studies suggest an association between maternal obesity and adverse neurodevelopmental outcomes in offspring. Objective: To compare the global proteomic portrait in the cerebral cortex between mice born to mothers on a high-fat or control diet who themselves were fed a h...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-29 | PXD001540 | Pride
2d lc-ms/ms Proteomics Brain Obesity High-fat diet Cerebral cortex Itraq Maternal 
TranscriptomicsEffects of dietary obesity in fathers on gene expression of islets in the female offspring
The global prevalence of obesity is increasing across age and gender. The rising burden of obesity in young people contributes to the early emergence of type 2 diabetes. Having one parent obese is an independent risk factor for childhood obesity. While the detrimental impact of diet-induced maternal...
ORGANISM(S): Rattus norvegicus 
2010-10-21 | E-GEOD-19877 | biostudies-arrayexpress
MetabolomicsFaecalibaculum rodentium as a key player in combating maternal obesity-induced labor disorders

The global rise in maternal obesity increases the risk of adverse maternal and neonatal outcomes. This study demonstrates that both long- (12 weeks) and short-term (gestational) exposure to a high-fat diet (HFD) induces uterine labor disorders, elevates stillbirth rates, and alters gut microbiota...

2025-08-22 | MTBLS12877 | MetaboLights
TranscriptomicsMaternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring (Gene expression data)
Scope: The ‘Predictive Adaptive Response’ hypothesis suggests the in utero environment when mismatched with the post-natal environment can influence later life health. Underlying mechanisms are poorly understood, but may involve gene transcription changes, regulated via epigenetic mechanisms. ...
ORGANISM(S): Mus musculus 
2017-05-22 | E-MTAB-4987 | biostudies-arrayexpress
TranscriptomicsIdentification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity
Maternal obesity programs the offspring to cardiovascular disease, insulin resistance, and obesity. We sequenced and profiled the cardiac miRNAs that were dysregulated in the hearts of baboon fetuses born to a high fat / high fructose diet fed mothers compared to a regular diet fed mothers. Fetal he...
ORGANISM(S): Papio hamadryas 
2013-02-01 | E-GEOD-43323 | biostudies-arrayexpress
GenomicsIdentify acetylation marks in adult mouse L4 vertebrae gene promoter regions from maternal high fat diet dams using H3K27ac ChIP-Seq
Genes with increased H3K27ac marks in their promoters were found in adult mice L4 vertebrae from mice using H3K27ac ChIP-Seq. Recent data suggests that in animals and humans that a maternal diet high in fat leads to poor bone growth and development in offspring. Genes with increased H3K27ac epigenet...
ORGANISM(S): Mus musculus 
2022-05-31 | E-MTAB-11718 | biostudies-arrayexpress
TranscriptomicsMaternal exposure to a Western-style diet causes differences in microbiota composition and gene expression in the intestine of suckling mouse pups
During the last few decades, the long-lasting consequences of nutritional programming during the early phase of life have become increasingly evident, but the effects of maternal nutrition on the developing intestine are currently still relatively underexplored. In this study, we investigated in mic...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-72705 | biostudies-arrayexpress
ProteomicsMulti-omics data integration reveals sex-dependent hippocampal programming by maternal high-fat diet during lactation in adult mouse offspring
Early-life exposure to high-fat diet (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in memory and metabolic homeostasis, few studies reported the impact of maternal HF on this structure. We assessed the effects of maternal HF du...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045639 | Pride
Maternal high-fat diet Multiomics Sexual dimorphism Hippocampus Lc-ms/ms 
TranscriptomicsMaternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring (DNA methylation data)
Abstract Scope: The ‘Predictive Adaptive Response’ hypothesis suggests the in utero environment when mismatched with the post-natal environment can influence later life health. Underlying mechanisms are poorly understood, but may involve gene transcription changes, regulated via epigenetic mech...
ORGANISM(S): Mus musculus 
2017-05-22 | E-MTAB-4990 | biostudies-arrayexpress
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