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ProteomicsA low-input proteomic analysis of mouse maternal-to-zygotic transition
Maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment of oocyte transits to the zygotic genome driven expression program, and terminally differentiated oocyte and sperm are reprogrammed to totipotency. It is initiated by maternal mRNAs and ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-27 | PXD041023 | Pride
Zygotic genome activation Maternal-to-zygotic transition Low-input proteomic technology Mouse embryo Mouse oocyte 
ProteomicsQuantitative proteomics reveals the dynamic proteome landscape of zebrafish embryos during maternal-to-zygotic transition and its relationship to zygotic genome activation
Upon fertilization, the embryonic genome remains transcriptionally inactive until the mid-blastula transition. Zygotic genome activation (ZGA) of vertebrate embryos has been extensively studied using nucleic acid-based strategies, but proteomics data are still scarce, impeding the full mechanistic u...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Xenopus laevis (African clawed frog) 
2024-05-01 | PXD036678 | Pride
Zygotic genome activation Zebrafish embryo Maternal-to-zygotic transition Quantitative proteomics 
ProteomicsUltrasensitive proteomics depicted an in-depth landscape for the very early stage of mouse maternal-to-zygotic transition
Maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment of oocyte transits to the zygotic genome driven expression program, and terminally differentiated oocyte and sperm are reprogrammed to totipotency. Metaphase II (MII) oocytes and zygotes...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-23 | PXD041399 | Pride
Mouse maternal-to-zygotic transition One-cell embryo Metaphase ii (mii) oocyte Ultrasensitive proteome technology 
GenomicsEstablishment of regions of genomic activity during the Drosophila maternal-to-zygotic transition
A conspicuous feature of early animal development is the lack of transcription from the embryonic genome, and it typically takes several hours to several days (depending on the species) until widespread transcription of the embryonic genome begins. Although this transition is ubiquitous, relatively ...
ORGANISM(S): Drosophila melanogaster 
2014-10-16 | E-GEOD-58935 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila embryos shows the zinc finger protein Zelda plays a key role in the maternal to zygotic transition
In all animals, the initial events of embryogenesis are controlled by maternal gene products that are deposited into the developing oocyte. At some point after fertilization, control of embryogenesis is transferred to the zygotic genome in a process called the maternal to zygotic transition (MZT). D...
ORGANISM(S): Drosophila melanogaster 
2008-11-22 | E-GEOD-11231 | biostudies-arrayexpress
ProteomicsDynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition
During the maternal-to-zygotic transition (MZT), transcriptionally silent embryos rely on post-transcriptional regulation of maternal mRNAs until zygotic genome activation (ZGA). RNA-binding proteins (RBPs) are important regulators of post-transcriptional RNA processing events, yet their identities ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2017-03-27 | PXD006098 | Pride
Embryo Zebrafish 
GenomicsZelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition
The earliest stages of development in most metazoans are driven by maternally deposited proteins and mRNAs, with widespread transcriptional activation of the zygotic genome occurring hours after fertilization, at a period known as the maternal-to-zygotic transition (MZT). In Drosophila, the MZT is p...
ORGANISM(S): Drosophila melanogaster 
2011-07-18 | E-GEOD-30757 | biostudies-arrayexpress
ProteomicsPrecise temporal regulation of post-transcriptional repressors is required for an orderly Drosophila maternal-to-zygotic transition
In animal embryos the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents over half of the protein coding capacity of the Drosophila melanogaster genome and that 2% of this proteome is rapidly degraded...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-09-09 | PXD018794 | Pride
C-terminal to lis1 homology (ctlh) complex Skp/cullin/f-box-containing (scf) complex Ubiquitin ligase Smaug Rna-binding protein 
ProteomicsPrecise temporal regulation of post-transcriptional repressors is required for an orderly Drosophila maternal-to-zygotic transition
In animal embryos the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents over half of the protein coding capacity of the Drosophila melanogaster genome and that 2% of this proteome is rapidly degraded...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-06-05 | PXD016523 | Pride
Development Mzt Ubiquitin Drosophila 
TranscriptomicsSMAUG is required for zygotic transcription during the maternal-zygotic transition MZT
Microarray analysis of zygotic gene expression in 2-to-3 hour wild-type (wt) and smg mutant embryos. Expression is relative to mature, stage 14 oocytes, which contain the full maternal pool of mRNA. Strictly maternal genes that are not transcribed at the MZT contribute approximately 80% of transc...
ORGANISM(S): Drosophila melanogaster 
2010-06-19 | E-GEOD-13287 | biostudies-arrayexpress
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