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ProteomicsMass-spectrometry analysis of the human pineal proteome during night and day and in autism.
Using mass spectrometry based proteomics and dedicated analysis tools, we identify proteins expressed in the human pineal gland and analyze systematically their variation with time of the throughout the day, and, compare these changes in the pineal proteome between control specimens and donors diagn...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020501 | Pride
Circadian Proteomics Pineal glands 
ProteomicsA novel chemical biology high-content strategy for the identification of novel HMT inhibitors reveals a crosstalk between DOT1L and CARM1
Epigenetic regulation is a dynamic and reversible process that controls gene expression. Abnormal function results in downregulation or upregulation of pathways leading to diseases, such as cancer. The enzymes that establish and maintain epigenetic marks, such as histone methyltransferases (HMTs), a...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD022873 | Pride
Histone methyltransferases 
ProteomicsImpact of gut microbiota on the m6A epitranscriptome in mouse cecum and liver tissues
The intestinal microbiota modulates host physiology and gene expression via mechanisms that are not fully understood. A recently discovered layer of gene expression regulation is N6-methyladenosine (m6A) and N6,2′ -O-dimethyladenosine (m6Am) modifications of mRNA. To unveil if these epitranscriptomi...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD016099 | Pride
Microbiota Mouse 
ProteomicsDIFFERENTIATION-DEPENDENT SUSCEPTIBILITY OF HUMAN MUSCLE CELLS TO ZIKA VIRUS INFECTION
Muscle cells are potential targets of many arboviruses, such as Ross River, Dengue, Sindbis, and Chikungunya viruses, that may be involved in the physiopathological course of the infection. During the recent outbreak of Zika virus (ZIKV), myalgia was one of the most frequently reported symptoms. We ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD017261 | Pride
Muscle differentiation virus infection proteomics 
Proteomicsimportance of MTFP1 for mitochondrial function in the heart
Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is essential for cardiac structure and function. Constitutive knockout of cardiomyocyte MTFP1 in mice resulted in adult-onset dilated cardiomyopathy (DCM) characte...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-06 | PXD028516 | Pride
Mouse Heart Mitochondria 
ProteomicsIn-depth characterization of the Clostridioides difficile phosphoproteome to identify Ser/Thr kinases substrates
Clostridioides difficile is the leading cause of intestinal nosocomial post-antibiotic infections in adults. During infection, the bacterium must rapidly respond and adapt to the host environment by using survival strategies. Protein phosphorylation is a reversible post-translational modification em...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-12-08 | PXD029827 | Pride
Phosphoproteomics Qexactive hf Clostridium difficile Kinase 
ProteomicsThe proteome of Tunneling Nanotubes (TNTs) in U2OS cells; comparison with Extracellular Vesicles (EVs)
Tunneling nanotubes (TNTs) are thin F-actin based membranous structures that form continuous cytoplasmic bridges between cells over distances ranging from several hundred nm up to 100 µm. They allow cell-to-cell communication by facilitating the transfer of different cargoes directly from cytoplasma...
ORGANISM(S): Homo sapiens (Human) 
2024-08-22 | PXD033089 | Pride
Lc-msms Tnts Exosomes Extracellular vesicles 
ProteomicsHepatic deletion of Mtfp1 enhances oxidative phosphorylation and cell death resistance to confer protection against liver disease _ REVISION
Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is essential for cardiac structure and function. Constitutive knockout of cardiomyocyte MTFP1 in mice resulted in adult-onset dilated cardiomyopathy (DCM) characte...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-05 | PXD034477 | Pride
Mouse Lfq Liver disease 
ProteomicsMtfp1 ablation enhances respiration and protects against hepatic steatosis
Hepatic steatosis is the result of an imbalance between nutrient delivery and metabolism in the liver. It is the first hallmark of Non-alcoholic fatty liver disease (NAFLD) and is characterized by the accumulation of excess lipids in the liver that can drive liver failure, inflammation, and cancer....
ORGANISM(S): Mus musculus (Mouse) 
2023-11-27 | PXD041197 | Pride
Oxidative phosphorylation Steatosis Mitochondria Liver Nafld 
ProteomicsEps8, Arp2/3 and IRSp53 in TNT formation
Tunneling nanotubes (TNTs) connect distant cells and mediate cargo transfer for intercellular communication in physiological and pathological contexts. How the cell controls a common pool of proteins to generate these actin-mediated protrusions spanning length scales beyond those attainable by canon...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD035976 | Pride
Tnt eps8 irsp53 
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