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ProteomicsMass-spectrometry analysis of the human pineal proteome during night and day and in autism.
Using mass spectrometry based proteomics and dedicated analysis tools, we identify proteins expressed in the human pineal gland and analyze systematically their variation with time of the throughout the day, and, compare these changes in the pineal proteome between control specimens and donors diagn...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020501 | Pride
Circadian Proteomics Pineal glands 
ProteomicsA novel chemical biology high-content strategy for the identification of novel HMT inhibitors reveals a crosstalk between DOT1L and CARM1
Epigenetic regulation is a dynamic and reversible process that controls gene expression. Abnormal function results in downregulation or upregulation of pathways leading to diseases, such as cancer. The enzymes that establish and maintain epigenetic marks, such as histone methyltransferases (HMTs), a...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD022873 | Pride
Histone methyltransferases 
ProteomicsImpact of gut microbiota on the m6A epitranscriptome in mouse cecum and liver tissues
The intestinal microbiota modulates host physiology and gene expression via mechanisms that are not fully understood. A recently discovered layer of gene expression regulation is N6-methyladenosine (m6A) and N6,2′ -O-dimethyladenosine (m6Am) modifications of mRNA. To unveil if these epitranscriptomi...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD016099 | Pride
Microbiota Mouse 
ProteomicsDIFFERENTIATION-DEPENDENT SUSCEPTIBILITY OF HUMAN MUSCLE CELLS TO ZIKA VIRUS INFECTION
Muscle cells are potential targets of many arboviruses, such as Ross River, Dengue, Sindbis, and Chikungunya viruses, that may be involved in the physiopathological course of the infection. During the recent outbreak of Zika virus (ZIKV), myalgia was one of the most frequently reported symptoms. We ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD017261 | Pride
Muscle differentiation virus infection proteomics 
ProteomicsIn-depth characterization of the Clostridioides difficile phosphoproteome to identify Ser/Thr kinases substrates
Clostridioides difficile is the leading cause of intestinal nosocomial post-antibiotic infections in adults. During infection, the bacterium must rapidly respond and adapt to the host environment by using survival strategies. Protein phosphorylation is a reversible post-translational modification em...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-12-08 | PXD029827 | Pride
Phosphoproteomics Qexactive hf Clostridium difficile Kinase 
ProteomicsComparison of the Human Neuronal Proteome upon Japanese Encephalitis or West Nile Virus Infection and potential role of mosquito saliva in neuropathogenesis
Neurotropic flavivirus Japanese encephalitis virus (JEV) and West Nile virus (WNV) are amongst the leading causes of encephalitis. Using label-free quantitative proteomics, we identified proteins differentially expressed upon JEV (gp-3, RP9) or WNV (IS98) infection of human neuroblastoma cells. Both...
ORGANISM(S): West Nile virus Culex pipiens pipiens Homo sapiens (Human) Japanese encephalitis virus 
2020-05-14 | PXD016805 | Pride
Mosquito Label free Japanese encephalitis West nile 
ProteomicsProteomics studies confirm CYP450 core involvement in multiple resistance strains of Aedes aegypti from French Guiana
Insecticide resistance is a worldwide threat for vector control around the world, and Aedes aegypti , the main vector of several arboviruses, is a particular concern. To better understand the mechanisms of resistance, four isofemale strains originally from French Guiana were isolated and analysed us...
ORGANISM(S): Aedes aegypti 
2020-12-09 | PXD020408 | Pride
Cyp Aedes aegypti Diagnostic concentration Insecticide resistance Multiple resistance 
ProteomicsNew insights into amebiasis using a human 3D-intestinal model
Entamoeba histolytica, the agent of amebiasis, colonizes the human colon and can invade the lining of the colon to disseminate in the deep layers of the intestine. Amebiasis mainly affects poor people in developing countries, where the barriers between human feces and food or water are inadequate. H...
ORGANISM(S): Homo sapiens (Human) Entamoeba histolytica HM-1:IMSS 
2020-03-24 | PXD015312 | Pride
Mass spectrometry Infection 3d-intestinal model 
Proteomicsimportance of MTFP1 for mitochondrial function in the heart
Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is essential for cardiac structure and function. Constitutive knockout of cardiomyocyte MTFP1 in mice resulted in adult-onset dilated cardiomyopathy (DCM) characte...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-06 | PXD028516 | Pride
Mouse Heart Mitochondria 
ProteomicsMtfp1 ablation enhances respiration and protects against hepatic steatosis
Hepatic steatosis is the result of an imbalance between nutrient delivery and metabolism in the liver. It is the first hallmark of Non-alcoholic fatty liver disease (NAFLD) and is characterized by the accumulation of excess lipids in the liver that can drive liver failure, inflammation, and cancer....
ORGANISM(S): Mus musculus (Mouse) 
2023-11-27 | PXD041197 | Pride
Oxidative phosphorylation Steatosis Mitochondria Liver Nafld 
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