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ProteomicsQuantitative Proteomics Reveal the Role of Matrine in Lipid Metabolism
Hyperlipidemia (HLP) can lead to cardiovascular diseases (CVDs) and other urgent diseases, such as myocardial infarction (MI) and stroke. So, early therapy for HLP is necessary. As existing drugs to treat HLP could not achieve the ideal effect for some patients, we have to find new drugs for HLP tre...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD045502 | Pride
Matrine Lipid metabolism Hyperlipidemia Proteomics 
GenomicsEffects of matrine on gene expression of myeloid leukemia cells
Effects of matrine on gene expression of myeloid leukemia cells
PRJNA830853 | ENA
GenomicsThe mechanism of cardiotoxicity induced by evodiamine and matrine was revealed by epitranscriptomics
The mechanism of cardiotoxicity induced by evodiamine and matrine was revealed by epitranscriptomics
PRJNA1147763 | ENA
TranscriptomicsThe mechanism of cardiotoxicity induced by evodiamine and matrine was revealed by epitranscriptomics
By using epitranscriptomics, the mechanism of cardiotoxicity induced by evodiamine and matrine was discovered. Experimental findings indicated that evodiamine and matrine altered m6A levels within the cells.
ORGANISM(S): Homo sapiens 
2024-08-20 | GSE274753 | GEO
TranscriptomicsEffects of matrine on gene expression of myeloid leukemia cells
To investigate the molecular mechanism of matrine's anti-myeloid leukemia effect, Acute myeloid leukemia cells HL-60 and U937 and chronic myeloid leukemia cells K562 were treated with 0.8mg/mL matrine for 30min and 24h, respectively. Then, RNA-Seq data before and after matrine treatment were used fo...
ORGANISM(S): Homo sapiens 
2022-11-09 | GSE201309 | GEO
TranscriptomicsDesign, synthesis and in vitro and in vivo biological evaluation of matrine derivatives as efficient anticancer agents with the characteristics of endoplasmic retic stress induction and apoptosis activation
Search for the anticancer pathway of matrine derivatives
ORGANISM(S): Homo sapiens 
2026-05-31 | GSE293232 | GEO
UnknownEffect of matrine on primary human hepatocytes in vitro.
Not available
S-EPMC4329302 | biostudies-literature
UnknownMatrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice.
Not available
S-EPMC8115053 | biostudies-literature
UnknownMatrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells.
Not available
S-EPMC5253620 | biostudies-literature
UnknownMatrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production.
Not available
S-EPMC8339414 | biostudies-literature
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