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TranscriptomicsTranscription profiling of human aortic biopsy samples having differing degrees of stiffness
BACKGROUND: Previous genomic studies with human tissues have compared differential gene expression between 2 conditions (ie, normal versus diseased) to identify altered gene expression in a binary manner; however, a potentially more informative approach is to correlate the levels of gene expression ...
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-420 | biostudies-arrayexpress
TranscriptomicsFeedback amplication of fibrosis through matrix stiffening and COX-2 suppression
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-22011 | biostudies-arrayexpress
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
ProteomicsTumor matrix stiffness induces CCN1/CYR61 upregulation of N-Cadherin to promote cancer cell trans-endothelial migration and metastasis
Tumor progression is often accompanied with increased extracellular matrix stiffness, but how this affects endothelial cells (ECs) is largely unknown. We used mass spectrometry to analyse the proteomic changes of primary human ECs cultured on physiological or tumor stiffness and found that CCN1/CYR6...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD003316 | Pride
Stiffness  protome  silac  ccn1  matrigel  huvec  tumour  vasculature 
TranscriptomicsRNA-seq of human skin fibroblasts from healthy and systemic sclerosis patients with varying matrix stiffness
This study explores how increased matrix stiffness alters fibroblast transcription and its impact on the lineage specification of fibroblast subpopulations in fibrotic skin. Fibroblasts from healthy and systemic sclerosis patients were cultured in a collagen I-based 3D system with varying matrix sti...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-14804 | biostudies-arrayexpress
ProteomicsThe proteomics data for Increased matrix stiffness promotes fibrogenesis of hepatic stellate cells through AP-1-induced chromatin priming
Matrix stiffness has significant effects on cell behavior, however, less is known regarding the epigenomic and transcriptional regulation underling the effect of matrix stiffness on cells. In this study, we use an in vitro system to assess the phenotypic shifts of hepatic stellate cells (HSCs) follo...
ORGANISM(S): Homo Sapiens 
2025-04-19 | PXD063173 |
GenomicsMatrix Stiffness-driven FAK Splicing Tunes Cell Mechanosensing
Matrix Stiffness-driven FAK Splicing Tunes Cell Mechanosensing
PRJNA1476708 | ENA
ProteomicsMatrix Stiffness-Driven Cytoskeletal Remodeling and Tumor Progression in Anaplastic Thyroid Cancer via Integrin-Focal Adhesion Kinase Signaling
Anaplastic thyroid cancer (ATC) is a highly lethal malignancy characterized by rapid progression and therapeutic resistance. This study uncovers the pivotal role of extracellular matrix (ECM) stiffness in driving ATC aggressiveness through mechanotransduction mediated by the Integrin α6β4/Focal Adhe...
ORGANISM(S): Homo Sapiens 
2025-08-07 | PXD067033 |
ProteomicsDysregulated Extracellular Matrix and Increased Stiffness in Lissencephaly Brain Organoid Models
LIS1 mutations are known to cause lissencephaly, a neurological disorder characterized by the absence of cerebral cortical convolutions. Here we show that brain organoids with LIS1 mutations exhibit increased expression of extracellular matrix (ECM) proteins, which are less organized. The mechanical...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD049178 | Pride
Extracellular matrix Brain Organoid 
ProteomicsSox9 accelerates vascular ageing by regulating extracellular matrix composition and stiffness
Vascular calcification and increased extracellular matrix (ECM) stiffness are hallmarks of vascular ageing. Sox9 (SRY-Box Transcription Factor 9) is a master regulator of chondrogenesis, also expressed in the vasculature, that has been implicated in vascular smooth muscle cell (VSMC) osteo-chondroge...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD046001 | Pride
Vascular smooth muscle cells Sox9 Extracellular matrix Senescence 
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