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ProteomicsAnalysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development
NOTCH1 (N1) is a transmembrane receptor interacting with membrane-tethered ligands on opposing cells that mediate the direct cell-cell interaction necessary for many cell fate decisions. Protein O-fucosyltransferase 1 (POFUT1) adds O-fucose to Epidermal Growth Factor (EGF)-like repeats in the NOTCH ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-02 | PXD050256 | Pride
Notch1 Mass spectrometry O-fucose Pofut1 
ProteomicsO-Fucose glycans on mouse NOTCH1 from activated T cells of Fringe mutant mice
NOTCH1 (N1) is a transmembrane receptor that initiates a cell-cell signaling pathway controlling various cell fate specifications in metazoans. The addition of O-fucose by Protein O-fucosyltransferase 1 (POFUT1) to Epidermal Growth Factor-like (EGF) repeats in the N1 extracellular domain is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD031297 | Pride
T cell Notch1 O-fucose Fringe Pofut1 
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