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MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
TranscriptomicsBiogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals (single embryo)
Parental dietary conditions can influence the metabolic traits of offspring. In mice, paternal consumption of low protein diet alters cholesterol and lipid metabolism of progeny. Here, we examine RNA species expressed in male reproductive tissues of mice. Protein restriction leads to altered levels ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-75765 | biostudies-arrayexpress
TranscriptomicsBiogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
Parental dietary conditions can influence the metabolic traits of offspring. In mice, paternal consumption of low protein diet alters cholesterol and lipid metabolism of progeny. Here, we examine RNA species expressed in male reproductive tissues of mice. Protein restriction leads to altered levels ...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-74537 | biostudies-arrayexpress
TranscriptomicsThe RNA binding protein Arrest (Aret) regulates myofibril maturation in Drosophila flight muscle
In Drosophila, fibrillar flight muscles (IFMs) enable flight, while tubular muscles mediate other body movements. Here, we use RNA-sequencing and isoform-specific reporters to show that spalt major (salm) determines fibrillar muscle physiology by regulating transcription and alternative splicing of ...
ORGANISM(S): Drosophila melanogaster 
2014-12-23 | E-GEOD-63707 | biostudies-arrayexpress
TranscriptomicsEffects of Dcp1a and Dcp2 knockdown during mouse oocyte maturation
Oocyte maturation is accompanied by a transition from mRNA stability to instability. We investigated the role of DCP1A and DCP2, proteins responsible for mRNA decapping, in mRNA destabilization during mouse oocyte maturation. siRNA-mediated knockdown of both Dcp1a and Dcp2 transcripts prior to ini...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-27049 | biostudies-arrayexpress
TranscriptomicsEffects of in vitro maturation on oocyte gene expression
In vitro oocyte maturation (IVM) holds great promise as a tool for enhancing clinical treatment of infertility, enhancing availability of non human primates for development of disease models, and facilitating endangered species preservation. However, IVM outcomes have remained significantly below s...
ORGANISM(S): Macaca mulatta 
2009-05-20 | E-GEOD-11895 | biostudies-arrayexpress
GenomicsPRC2 proteins EZH1 and EZH2 regulate postnatal hepatic maturation [RNA-Seq]
PRC2 proteins EZH1 and EZH2 regulate postnatal hepatic maturation [RNA-Seq]
PRJNA486739 | ENA
GenomicsPRC2 proteins EZH1 and EZH2 regulate postnatal hepatic maturation [ChIP-Seq]
PRC2 proteins EZH1 and EZH2 regulate postnatal hepatic maturation [ChIP-Seq]
PRJNA488187 | ENA
GenomicsPRC2 proteins EZH1 and EZH2 regulate postnatal hepatic maturation [RNA-seq2]
PRC2 proteins EZH1 and EZH2 regulate postnatal hepatic maturation [RNA-seq2]
PRJNA516682 | ENA
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