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ProteomicsRat Kidney MS analysis with dehydration and cyclosporine treatment
Background- CINAC-patients can be identified by the recently discovered renal proximal tubular cell lysosomal lesions which are also observed in patients experiencing calcineurin inhibitor (CNI) nephrotoxicity, suggesting that CINAC is a toxin-induced nephropathy. An alternative hypothesis advocates...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-11-14 | PXD038062 | Pride
Kidney ms dehydration cyclosporine 
TranscriptomicsStromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells
The identified stromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. Human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons are potentially useful for treating Parkinson’s disease (PD) through cell replacement therapy. Gen...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-20503 | biostudies-arrayexpress
UnknownBenign ethnic neutropenia: an analysis of prevalence, timing and identification accuracy in two large inner-city NHS hospitals.
Not available
S-EPMC8515765 | biostudies-literature
TranscriptomicsEuglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington's disease is related to their physiological efficacy
Our aim was to find an effective treatment for the dysfunction in energy regulation and hypothalamic integrity occurring in many HuntingtonM-bM-^@M-^Ys disease (HD) patients and mouse models. HD is a neurodegenerative disease caused by an expanded CAG repeat and is characterized by mutant huntingtin...
ORGANISM(S): Mus musculus 
2012-10-05 | E-GEOD-39586 | biostudies-arrayexpress
TranscriptomicsMultiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes
The central nervous system normally functions at O2 levels which would be regarded as hypoxic by most other tissues. However, most in vitro studies of neurons and astrocytes are conducted under hyperoxic conditions without consideration of O2-dependent cellular adaptation. We analyzed the reactivi...
ORGANISM(S): Rattus norvegicus 
2012-09-20 | E-GEOD-29296 | biostudies-arrayexpress
TranscriptomicsAmitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer’s disease mice is associated with neurogenesis and neurotrophic activity
Approximately 35 million people worldwide suffer from Alzheimer’s disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence. AD is associated with an increase in amyloid beta (A) oligomers and hyperphosphorylated tau, along wit...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-26836 | biostudies-arrayexpress
TranscriptomicsResveratrol prevents diet-induced arterial degeneration and stiffening in nonhuman primates
Cardiovascular (CV) disease is a leading cause of morbidity and mortality in Western societies. Even after accounting for traditional CV risk factors (e.g. obesity, smoking and hypertension), the inflammation-driven thickening and stiffening of central arteries is a strong predictor of adverse outco...
ORGANISM(S): Macaca mulatta 
2014-07-21 | E-GEOD-45927 | biostudies-arrayexpress
UnknownIncidence of anorexia nervosa in young people in the UK and Ireland: a national surveillance study.
Not available
S-EPMC6954494 | biostudies-literature
UnknownA scoping review of trauma informed approaches in acute, crisis, emergency, and residential mental health care.
Not available
S-EPMC10405430 | biostudies-literature
UnknownExome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.
Not available
S-EPMC5886170 | biostudies-literature
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