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TranscriptomicsTranscription profiling of mouse neurobastoma N18 cell line transfected with a pAd-Dyrk1a vector
The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located ...
ORGANISM(S): Mus musculus 
2009-02-27 | E-GEOD-14030 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse stage E12.5 telencephalon from 152F7 transgenic mouse
The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located ...
ORGANISM(S): Mus musculus 
2009-02-27 | E-GEOD-14021 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E12.5 telencephalon from 152F7 transgenic mouse and neuroblastoma N18 cell line tranfected with a pAd-Dyrk1a vector
This SuperSeries is composed of the following subset Series:; GSE14021: Transcriptional analysis of E12.5 telencephalon from 152F7 transgenic mouse; GSE14030: Transcriptional analysis of murine neurobastoma N18 cell line transfected with a pAd-Dyrk1a vector Experiment Overall Design: Refer to indivi...
ORGANISM(S): Mus musculus 
2009-02-27 | E-GEOD-14105 | biostudies-arrayexpress
Transcriptomicsdyrk1a
Transcription profiling of transgenic down syndrome mouse model to show the role of DYRK1A gene. The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse m...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14072 | biostudies-arrayexpress
TranscriptomicsDifferential microRNA profile in frontal cortex of suicide completers compared to control
Background: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly expressed in astrocytes and regulates BDNF-evoked calcium transients. Previous studies indicate that downregulation of TrkB-T1 in frontal cortex may be involved in neurobiological processes underlying suicide. Me...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-34120 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of subthalamic nuclei from mice submitted to a short-term cocaine-dependent conditioned place preference
Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to ide...
ORGANISM(S): Mus musculus 
2015-05-10 | E-GEOD-28523 | biostudies-arrayexpress
TranscriptomicsTranscriptome of globus pallidus from a mouse having a high score of cocaine-dependent conditioned place preference
Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to ide...
ORGANISM(S): Mus musculus 
2015-05-10 | E-GEOD-28528 | biostudies-arrayexpress
TranscriptomicsTranscriptome of globus pallidus from a mouse having a low score of cocaine-dependent conditioned place preference
Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to ide...
ORGANISM(S): Mus musculus 
2015-05-10 | E-GEOD-28527 | biostudies-arrayexpress
TranscriptomicsTranscriptome of accumbens nuclei from mice having low scores of cocaine-dependent conditioned place preference
Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to ide...
ORGANISM(S): Mus musculus 
2015-05-10 | E-GEOD-28529 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of accumbens nuclei from mice submitted to a short-term cocaine-dependent conditioned place preference
Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to ide...
ORGANISM(S): Mus musculus 
2015-05-10 | E-GEOD-28531 | biostudies-arrayexpress
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