Sort   by:  
 Page size 
ProteomicsEffect of PTEN knockout on dabrafenib-trametinib treatment in A375 melanoma cells - replicate 1
Approximately 50% of melanomas harbor an activating BRAFV600E mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the substrate for BRAF in the MAPK pathway. PTEN loss of function mutations occur in 40% of BRAFV600E melanomas, resulting in increased PI3K...
ORGANISM(S): Homo sapiens (Human) 
2024-04-23 | PXD033866 | Pride
A375 Kinase inhibitor Braf Melanoma Mek Kinome 
ProteomicsEffect of PTEN knockout on dabrafenib-trametinib treatment in A375 melanoma cells - replicate 2
Approximately 50% of melanomas harbor an activating BRAFV600E mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the substrate for BRAF in the MAPK pathway. PTEN loss of function mutations occur in 40% of BRAFV600E melanomas, resulting in increased PI3K...
ORGANISM(S): Homo sapiens (Human) 
2024-04-23 | PXD033921 | Pride
A375 Kinase inhibitor Braf Melanoma Mek Kinome 
ProteomicsKinome profiling of shControl and shFANCA THP1 cells treated with volasertib
The Fanconi anemia (FA) pathway is a network of proteins critical to the preservation of genomic integrity and the prevention of cancer. FA proteins safeguard the genome by regulating the cell cycle and facilitating error-free repair of DNA damage. Bi-allelic mutation of genes encoding FA pathway pr...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD048057 | Pride
Polo-like kinase 1 Kinase inhibitor Acute myeloid leukemia Fanconi anemia 
UnknownMutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation.
Not available
S-EPMC3928656 | biostudies-literature
UnknownEstablishing a core outcome set for mucopolysaccharidoses (MPS) in children: study protocol for a rapid literature review, candidate outcomes survey, and Delphi surveys.
Not available
S-EPMC8600749 | biostudies-literature
GenomicsHistone Modifications by ChIP-seq from ENCODE/Caltech
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Barbara Wold mailto:woldb@caltech.edu, Georgi K. Marinov mailto:georgi@caltech.edu, Diane Trout mailto:diane@caltech.edu). If you have questions about the Genome Browser track associa...
ORGANISM(S): Mus musculus 
2012-04-19 | E-GEOD-36023 | biostudies-arrayexpress
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownGlobal COVID-19 lockdown highlights humans as both threats and custodians of the environment.
Not available
S-EPMC8135229 | biostudies-literature
UnknownGenome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
Not available
S-EPMC11245051 | biostudies-literature
Sort   by:  
 Page size