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TranscriptomicsTranscription profiling of mouse PyV-MT treated with conjugated linoleic acid reveals it suppresses FAS and promotes mammary tumorigenesis in mice
Overexpression of fatty acid synthase (FAS) has been reported in both malignant and premalignant breast lesions, and has been associated with poor outcome. FAS has gained interest as a metabolic target for the treatment of breast cancer based on evidence that blockade with the antifungal antibiotic,...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10193 | biostudies-arrayexpress
TranscriptomicsThe effect of dietary CLA on mammary tumorigenesis
Conjugated linoleic acid (CLA), a class of fatty acids found in beef and dairy products, has been shown to inhibit tumorigenesis in a variety of cancer model systems. Based on previously well-documented anti-tumor activity of CLA in rodent models of breast cancer, a pilot study was initiated to exam...
ORGANISM(S): Mus musculus 
2008-11-18 | E-GEOD-13553 | biostudies-arrayexpress
UnknownWounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model.
Not available
S-EPMC6032528 | biostudies-literature
UnknownCommensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Not available
S-EPMC6691977 | biostudies-literature
UnknownRacial/ethnic disparities in hypertension prevalence: reconsidering the role of chronic stress.
Not available
S-EPMC3910029 | biostudies-literature
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
ProteomicsVincristine resistance reshapes sphingolipid composition and promotes mitochondrial complex I deficiency in acute myelogenous leukemia
Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer treatment, are no exception, as their beneficial actio...
ORGANISM(S): Homo Sapiens (human) 
2022-04-21 | PXD025645 | JPOST Repository
TranscriptomicsNkx2.1 represses a latent gastric differentiation program in lung adenocarcinoma
During cancer evolution, cellular differentiation programs become dysregulated. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of lung ep...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-36473 | biostudies-arrayexpress
UnknownPhase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G.
Not available
S-EPMC8637652 | biostudies-literature
UnknownStructures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32.
Not available
S-EPMC11621456 | biostudies-literature
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