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ProteomicsA human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
The human genome consists of considerable portions derived from retroviruses typically inherited already for millions of years. So-called human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERV sequences exist. The HERV-K(HML-2) group includes evolutionaril...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD010159 | Pride
Protease N-terminomics 
ProteomicsA human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
Background: The human genome consists of considerable portions derived from retroviruses inherited for millions of years. So-called human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERVs exist. The HERV-K(HML-2) group includes evolutionarily young proviru...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD013296 | Pride
Proteolysis Retrovirus 
ProteomicsHERV protease specificity - Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics
Proteome-derived peptide libraries are a powerful tool for the investigation of protease specificity, conventionally involving the biotinylation of cleavage products to enable for their enrichment. Here we present a modified strategy for protease specificity profiling using proteome-derived peptide ...
ORGANISM(S): Escherichia coli 
2016-05-02 | PXD003833 | Pride
Protease 
ProteomicsTag-Free Identification of Protease Specificity Using Proteome-Derived Peptide Libraries
Proteome-derived peptide libraries are a powerful tool for the investigation of protease specificity, conventionally involving the biotinylation of cleavage products to enable for their enrichment. Here we present a modified strategy for protease specificity profiling using proteome-derived peptide ...
ORGANISM(S): Escherichia coli 
2016-05-02 | PXD002785 | Pride
Proteolysis 
ProteomicsThe Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR are Based on Highly Similar Proteome and Degradome Alterations
ADAM17 and EGFR are essential key players for epidermal integrity. Keratinocyte-specific deletion of ADAM17 in mice results in pronounced alterations in terminal differentiation of keratinocytes leading to severe epidermal barrier defects with enhanced transepidermal water loss. Thereby, mice defici...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-20 | PXD002597 | Pride
Proteomics Skin Degradomics 
UnknownProthrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.
Not available
S-EPMC11955085 | biostudies-literature
UnknownEffect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial.
Not available
S-EPMC9204623 | biostudies-literature
UnknownGenome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.
Not available
S-EPMC6288131 | biostudies-literature
UnknownProtocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial.
Not available
S-EPMC11344867 | biostudies-literature
UnknownAssessing the genetic association between vitamin B6 metabolism and genetic generalized epilepsy.
Not available
S-EPMC6796782 | biostudies-literature
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