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We identified a novel paralog of the antioxidant response element transcription factor, Nrf2 in zebrafish. To determine whether the paralogs Nrf2a and Nrf2b regulate different sets of genes, we performed loss-of-function experiments followed by microarray-based gene expression profiling, performed ...
ORGANISM(S): Danio rerio 
The goal of this study was to map DNaseI sensitivity and DNaseI hypersensitive sites over the ENCODE regions in human lymphoblastoid cells (GM06990, Coriell). DNA fragments released from DNaseI cut sites in nuclear chromatin were collected and hybridized to the Nimblegen ENCODE array. DNaseI-fragme...
ORGANISM(S): Homo sapiens 
Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis as well as to cardiovascular and neurodegenerative diseases. Developing animals may be especially sensitive to chemicals causing oxidative stress. To assess the response to chemicals at different stages of...
ORGANISM(S): Danio rerio 
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