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GenomicsGenome-wide methylation maps for Proliferating and Senescent cells
Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence imposes a limit on proliferative potential that all cancer cells must bypass. Compared to proliferating cells, senescent cells exhibit marked chromatin re-organizat...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-GEOD-48580 | biostudies-arrayexpress
TranscriptomicsExpression data from Control, Uninfected and BRAF infected cells
Melanocytes within benign human nevi are the paradigm for tumor suppressive senescent cells in a pre-malignant neoplasm. These cells typically contain mutations in either the BRAF or N-RAS oncogene and express markers of senescence, including p16. However, a nevus can contain 10s to 100s of thousand...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-46801 | biostudies-arrayexpress
TranscriptomicsPlacing the HIRA histone chaperone complex in the chromatin landscape
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-04-18 | E-GEOD-45025 | biostudies-arrayexpress
TranscriptomicsExpression data from 7 Human Melanomas
Melanocytes within benign human nevi are the paradigm for tumor suppressive senescent cells in a pre-malignant neoplasm. These cells typically contain mutations in either the BRAF or N-RAS oncogene and express markers of senescence, including p16. However, a nevus can contain 10s to 100s of thousand...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-46817 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state for H3.3 tagged cells
The HIRA chaperone complex, comprised of HIRA, UBN1 and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner. To better understand its function and mechanism, we integrated HIRA, UBN1, ASF1a and histone H3....
ORGANISM(S): Homo sapiens 
2013-04-18 | E-GEOD-45023 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state for HIRA, UBN1 and ASF1a
The HIRA chaperone complex, comprised of HIRA, UBN1 and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner. To better understand its function and mechanism, we integrated HIRA, UBN1, ASF1a and histone H3....
ORGANISM(S): Homo sapiens 
2013-04-18 | E-GEOD-45024 | biostudies-arrayexpress
TranscriptomicsExpression data from Control, AKT and RAS transduced cells
Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes in the same pathway is unclear. Based on a comparative molecular analysis, we show that ac...
ORGANISM(S): Homo sapiens 
2013-03-19 | E-GEOD-45276 | biostudies-arrayexpress
TranscriptomicsExpression data from control infected and H-RASG12V infected IMR90 cells.
Cellular senescence is a stable proliferation arrest associated with an altered secretory pathway, the Senescence-Associated Secretory Phenotype (SASP). However, cellular senescence is initiated by diverse molecular triggers, such as activated oncogenes and shortened telomeres, and is associated wit...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-54402 | biostudies-arrayexpress
GenomicsGenome-wide methylation maps for untreated and Aza treated AML3 cells
AML3 cells were treated with Azacytidine and compared against untreated cells Examination of methylation status in human untreated and Azacytidine treated AML3 cells
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55124 | biostudies-arrayexpress
TranscriptomicsMicroarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts
Gene expression approach to differences in stress response between human skin fibroblasts derived from chronologically young (~20 years) and old (~90 years) subjects. Expression of CDKN2A was most different between fibroblasts from young and old subjects and Human skin fibroblasts were isolated from...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-28300 | biostudies-arrayexpress
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