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TranscriptomicsDifferential gene expression is not correlated to age-related vascular pathology in aorta and mesenteric artery of Brown Norway and Fischer344xBrown Norway rats
Novel genetic pathways associated with successful and/or unsuccessful vascular aging Customized therapies for vascular disease will require matching the vessel type and genetic background of the patient. Our previous studies showed that progressive age-related vascular pathology is strain specific i...
ORGANISM(S): Rattus norvegicus 
2015-03-02 | E-GEOD-55612 | biostudies-arrayexpress
TranscriptomicsToxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes
Parasitic protozoa such as the apicomplexan Toxoplasma gondii progress through their life cycle in response to stimuli in the environment or host organism. Very little is known about how proliferating tachyzoites reprogram their expressed genome in response to stresses that prompt development into ...
ORGANISM(S): Toxoplasma gondii 
2011-05-25 | E-GEOD-22100 | biostudies-arrayexpress
TranscriptomicsMicroarray to find CHOP dependent genes in response to proteasome inhibition
Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the Integrated stress response (ISR). Depending on the extent of protein disrupti...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43713 | biostudies-arrayexpress
TranscriptomicsMicroarray to find ATF5 dependent genes in response to proteasome inhibition
Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the Integrated stress response (ISR). Depending on the extent of protein disrupti...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43714 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hepatitis PBMC C patients treated with Peg-interferon alfa-2b plus ribavirin during the first 10 weeks of treatment
Study of PBMC gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntronTM) and ribavirin (administered by weight) in HCV patients. This study compared the kinetics of gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntr...
ORGANISM(S): Homo sapiens 
2009-05-03 | E-GEOD-11342 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers from 74-day old male rats fed vitamin A sufficient or vitamin A deficient diet for 53 days
Analysis of livers from 74-day old male rats fed vitamin A sufficient or vitamin A deficient diet for 53 days. Either 10ug or 2ug of total RNA used in standard Affymetrix protocol
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-1600 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 cell line treated with type I and II interferons vs. controls
Type I and type II interferons (IFNs) bind to different cell surface receptors but activate overlapping signal transduction pathways. We examined the effects of a type I IFN (IFN-acon1) and a type II iFN (IFN-g1b) on gene experession in A549 cells and demonstrate that there is a common set of genes ...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-5542 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hepatitis C patients - responders and non-responders to antiviral therapies peg interferon and ribavirin against hepatitis C
Time series of gene expression arrays before and during treatment of Hepatitis C; days 0, 1, 2, 7, 14 and 28 for 69 participants (IDs 1 through 69 are used). Treating chronic hepatitis C using peginterferon alpha and ribavirin leads to sustained clearance of virus and clinical improvement in approxi...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-7123 | biostudies-arrayexpress
TranscriptomicsEthanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects
Gene expression was measured using microarrays in 8 hour postfertilization embryos, comparing control versus ethanol-treated (2 to 8 hours postfertilization) embryos. This experiment was performed to determine the gene expression changes that occur in response to ethanol treatment as a model of feta...
ORGANISM(S): Danio rerio 
2014-07-09 | E-GEOD-48380 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD14+ peripheral blood monocytes from subjects infected with H.drcreyi reveals host susceptibility to H. ducreyi infection is associated with unique transcript profiles in tissue and dendritic cells
Comparison of gene expression from subjects who resolved or formed pustules to H.ducreyi. In human inoculation experiments, the cutaneous immune response to Haemophilus ducreyi consists of serum, PMN, macrophages, T cells and myeloid DC. In reinfection experiments, some subjects form pustules twice...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5547 | biostudies-arrayexpress
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