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TranscriptomicsExpression profile of HCT116 p53+/+ and P53-/- cells treated with Leptomycin B
HCT116 wild type cells express p53. The isogenic HCT116 p53KO cells have the p53 gene knocked out. Cells were treated for 16 hours. Dosages for leptomycin B treatment was 2 nM and 20 nM. Measuring the gene expression profile of the isogenic cell lines when the cells were treated with leptomycin B at...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-17472 | biostudies-arrayexpress
TranscriptomicspCREB-dependent transcriptional activation is a mediator of molecular neuroadaptations induced by methamphetamine self-administration in the rat dorsal striatum
Neuroplastic changes in the dorsal striatum participate in the transition from casual drug use to habitual and compulsive drug taking. These alterations might also play a critical role in the development of methamphetamine (METH) addiction. Nevertheless, the molecular substrates that underlie habitu...
ORGANISM(S): Rattus norvegicus 
2012-05-31 | E-GEOD-38223 | biostudies-arrayexpress
Transcriptomics"Calling Cards" for DNA-binding proteins in mammalian cells
The ability to chronicle transcription factor binding events throughout the development of an organism would facilitate mapping of transcriptional networks that control cell fate decisions. We describe a method for permanently recording protein-DNA interactions in mammalian cells. We endow transcri...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-34791 | biostudies-arrayexpress
TranscriptomicsA comprehensive view of the transcriptome during development of the mouse cerebral cortex
The complexity of the mature adult brain is a result of both developmental processes and experience-dependent circuit formation. One way to look at the process of brain development is to examine gene expression changes, and previous studies have used microarrays to address this in a global manner. H...
ORGANISM(S): Mus musculus 
2013-02-10 | E-GEOD-39866 | biostudies-arrayexpress
UnknownAn Intervention Using Gamification to Increase Human Immunodeficiency Virus and Sexually Transmitted Infection Screening Among Young Men Who Have Sex With Men in California: Rationale and Design of Stick To It.
Not available
S-EPMC5537559 | biostudies-literature
TranscriptomicsTranscriptome profiling in 6-hydroxydopamine hemiparkinsonian rats reveals methamphetamine-mediated dopamine-independent changes in striatal gene expression.
Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle (MFB) is used extensively as a model of Parkinson’s disease. The present experiments examined whether a single injection of methamphetamine (METH) (2.5 mg/kg) could still influence striatal gene expression after 6-hydroxydop...
ORGANISM(S): Rattus norvegicus 
2010-09-21 | E-GEOD-24233 | biostudies-arrayexpress
UnknownHost microbiota constantly control maturation and function of microglia in the CNS.
Not available
S-EPMC5528863 | biostudies-literature
TranscriptomicsscRNA-seq of vertebrobasilar aneurysm in polyarteritis nodosa patient
Endovascular biopsy and fluorescence activated cell sorting was used to enrich for viable endothelial cells (ECs) from a vertebrobasilar aneurysm and the femoral artery. scRNAseq was then performed on 24 aneurysmal endothelial cells and 23 patient-matched non-aneurysmal femoral artery endothelial ce...
ORGANISM(S): Homo sapiens 
2021-07-01 | E-MTAB-10681 | biostudies-arrayexpress
UnknownEvolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike.
Not available
S-SCDT-EMBOR-2021-54322V1 | biostudies-other
UnknownIntegrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.
Not available
S-EPMC9470534 | biostudies-literature
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