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TranscriptomicsExposure to Propylthiouracil in Pregnant Mice Potentiates the Transcriptional Response to Thyroid Hormone in the Fetal Cerebral Cortex
Although the effects of thyroid hormones (TH) on the brain development have been extensively studied perinatally, effects of TH of maternal origin on the fetal brain development have been largely unexplored. We applied a high throughput study on the mouse models with aberrant TH levels on gestation ...
ORGANISM(S): Mus musculus 
2014-02-04 | E-GEOD-43927 | biostudies-arrayexpress
TranscriptomicsExpression profile for BW25113 M-NM-^TmqsRA with deoxycholate stress
MqsR/MqsA is a well-characterized toxin/antitoxin system with several regulatory roles. Deletion of mqsRA reduced growth with deoxycholate stress. Here we performed a microarray to determine the expression profile with and without mqsRA under deoxycholate stress to determine transcriptional regulat...
ORGANISM(S): Escherichia coli BW25113 
2015-01-09 | E-GEOD-59441 | biostudies-arrayexpress
TranscriptomicsPersistence of BW25113 mqsR producing MqsR 2-1 vs. producing wild-type MqsR with ampicillin
Persisters are a subpopulation of metabolically-dormant cells in biofilms that are resistant to antibiotics; hence, understanding persister cell formation is important for controlling bacterial infections. Previously we discerned that MqsR and MqsA of Escherichia coli are a toxin/antitoxin pair that...
ORGANISM(S): Escherichia coli K-12 
2012-04-02 | E-GEOD-31054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal v early MDS v non-MDS anemia bone marrow CD34 cells to identify biomarkers of disease
Early, low risk IPSS (International Prognostic Scoring System) myelodysplasia (MDS) is a heterogeneous disorder where the molecular and cellular haematopoietic defects are poorly understood. To gain insight into this condition, we analyzed gene expression profiles of marrow CD34+ progenitor cells fr...
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-2779 | biostudies-arrayexpress
TranscriptomicsMicroarray for suspension cells of PA14 WT with and without NE (50 uM and 500 uM) for 7 h
It has been proposed that the gastro-intestinal tract environment containing high levels of neuroendocrine hormones is important for gut-derived P. aeruginosa infections. In this study, we report that the hormone norepinephrine increases P. aeruginosa PA14 growth, virulence factor production, invasi...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2009-08-27 | E-GEOD-13326 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NFIA deficient mice brain
Background. Nuclear factor I-A (NFI-A), a phylogenetically conserved transcription/replication protein, plays a crucial role in mouse brain development. Previous studies showed that disruption of the Nfia gene in mice leads to perinatal lethality, corpus callosum agenesis, and hydrocephalus. Result...
ORGANISM(S): Mus musculus 
2009-04-24 | E-GEOD-4623 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of rat jejunum treated with MLT-943, a small molecule MALT1 protease inhibitor
MALT1 protease inhibition is effective in several preclinical models of autoimmunity and B cell malignancies. However, severe reduction in regulatory T cells (Tregs) and an associated IPEX-like pathology was observed in mice with congenital deficiency of MALT1. Rats treated with MLT-943, a novel pot...
ORGANISM(S): Rattus norvegicus 
2020-04-30 | E-MTAB-8990 | biostudies-arrayexpress
TranscriptomicsP. aeruginosa PA14 WT in LB medium vs in LB with 10 mM adenosine medium
To investigate the impact of adenosine on gene expression of wild-type PA14. To investigate the impact of adenosine on gene expression of wild-type PA14, cells were harvested after incubating for 7 h in LB medium and LB with 10 mM adenosine medium, and RNA was extracted with the RNeasy Mini Kit (Qia...
ORGANISM(S): Pseudomonas aeruginosa 
2012-05-22 | E-GEOD-29665 | biostudies-arrayexpress
TranscriptomicsThe multifaceted balance of TNF-a and type I / II interferon responses in SLE and RA: how monocytes manage the impact of cytokines
Many cytokines are involved in the pathogenesis of autoimmune diseases and are recognized as relevant therapeutic targets to attenuate inflammation, such as TNFα in RA and IFNα/γ in SLE. To relate the transcriptional imprinting of cytokines in a cell type-specific and disease-specific manner, we gen...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-38351 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans late larvae and adult developmental stages treated with low-intensity microwave irradiation reveals no substantial alteration in gene expression
Reports that low-intensity microwave radiation can induce heat-shock reporter gene expression in the nematode, Caenorhabditis elegans, have recently been reinterpreted as a subtle thermal effect caused by very slight heating. This study used a microwave exposure system (1.0 GHz, 0.5 W power input; ...
ORGANISM(S): Caenorhabditis elegans 
2009-03-20 | E-GEOD-10787 | biostudies-arrayexpress
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