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TranscriptomicsAxin2/Runx2 mouse calvaria gene expression
Runx2 and Axin2 regulate skeletal development. We recently determined that Axin2 and Runx2 molecularly interact in differentiating osteoblasts to regulate intramembranous bone formation, but the relationship between these factors in endochondral bone formation was unresolved. To address this, we exa...
ORGANISM(S): Mus musculus 
2014-07-04 | E-GEOD-59081 | biostudies-arrayexpress
ProteomicsInhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
This project aimed to assess the role of pharmacological inhibition of the aryl hydrocarbon receptor (AhR) on skeletal muscle and cortical bone health in aged mice. As part of a broader systems biology approach, proteomic profiling was employed to investigate molecular mediators of neuromuscular jun...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-06 | PXD065529 | Pride
Lc-msms  aryl hydrocarbon receptor  proteomics 
TranscriptomicsRUNX3 Facilitates Growth of Ewing Sarcoma Cells
Ewing sarcoma is an aggressive pediatric small round cell tumor that predominantly occurs in bone. Approximately 85% of Ewing sarcomas harbor the EWS/FLI fusion protein, which arises from a chromosomal translocation, t(11:22)(q24:q12). EWS/FLI interacts with numerous lineage-essential transcription...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56900 | biostudies-arrayexpress
GenomicsHistone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone 4 (H4) Epigenome (ChIP-Seq)
ChIP-Seq analysis revealed that suberoylanilidehydroxamic acid (SAHA) increases genome-wide H4 acetylation in differentially regulated genes, except for the 500 bp upstream of transcription start sites (TSS). Chromatin immunoprecipitation (ChIP) with massively parallel high throughput sequencing (Se...
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-50551 | biostudies-arrayexpress
TranscriptomicsHistone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone 4 (H4) Epigenome (BeadChip)
Suberoylanilidehydroxamic acid (SAHA) significantly increased the expression levels of 127 transcripts and suppressed expression of 130 genes by more than 2-fold within 3 standard deviations of the mean in differentiating MC3T3 sc4 osteoblasts Total RNA was obtained from differentiating MC3T3 sc4 c...
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-50549 | biostudies-arrayexpress
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