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ProteomicsAsparaginase and GSK3A inhibitor treatment of CCRF-CEM cells
Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activa...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013061 | Pride
Gsk3 Leukemia Asparaginase 
UnknownZNF410 represses fetal globin by singular control of CHD4.
Not available
S-EPMC8180380 | biostudies-literature
UnknownInterleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway.
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S-EPMC6678670 | biostudies-literature
UnknownGeneration of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins.
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S-EPMC2373471 | biostudies-literature
UnknownSupramolecular assembly of GSK3α as a cellular response to amino acid starvation.
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S-EPMC9357031 | biostudies-literature
UnknownRational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.
Not available
S-EPMC6650275 | biostudies-literature
UnknownSynthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias.
Not available
S-EPMC6541931 | biostudies-literature
UnknownFunctional divergence in gastrointestinal microbiota in physically-separated genetically identical mice.
Not available
S-EPMC4069701 | biostudies-literature
UnknownGut microbiota shape the inflammatory response in mice with an epithelial defect.
Not available
S-EPMC7928202 | biostudies-literature
UnknownInterleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells.
Not available
S-EPMC10494524 | biostudies-literature
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