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UnknownRecurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.
Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML). We used whole-genome sequencing to perform an unbiased comprehensive screen to discover the somatic mutations in a sample from an individual wi...
S-EPMC3247063 | biostudies-literature
UnknownThe association of skin intrinsic fluorescence with type 1 diabetes complications in the DCCT/EDIC study.

Objective

To determine whether skin intrinsic fluorescence (SIF) is associated with long-term complications of type 1 diabetes (T1D) and, if so, whether it is independent of chronic glycemic exposure and previous intensive therapy.

Research design and methods

We studied 1,185 (92%) of...
S-EPMC3781515 | biostudies-literature
UnknownEarly cross-coronavirus reactive signatures of humoral immunity against COVID-19.
The introduction of vaccines has inspired hope in the battle against SARS-CoV-2. However, the emergence of viral variants, in the absence of potent antivirals, has left the world struggling with the uncertain nature of this disease. Antibodies currently represent the strongest correlate of immunity ...
S-EPMC8943686 | biostudies-literature
UnknownGenome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.
Refractive error (RE) is a complex, multifactorial disorder characterized by a mismatch between the optical power of the eye and its axial length that causes object images to be focused off the retina. The two major subtypes of RE are myopia (nearsightedness) and hyperopia (farsightedness), which re...
S-EPMC4169415 | biostudies-literature
UnknownModern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005).

Background

Clinical treatment goals of type 1 diabetes mellitus (T1DM) have changed since the Diabetes Control and Complications Trial (DCCT) demonstrated reduced long-term complications with intensive diabetes therapy. There have been few longitudinal studies to describe the clinical course...
S-EPMC2866072 | biostudies-literature
UnknownCaffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes.

Background

A variant (rs1495741) in the gene for the N-acetyltransferase 2 (NAT2) protein is associated with skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation end products and other fluorophores in the skin. Because NAT2 is involved in caffeine metabolism, we aim...
S-EPMC4575521 | biostudies-literature
UnknownThe long-term effects of type 1 diabetes treatment and complications on health-related quality of life: a 23-year follow-up of the Diabetes Control and Complications/Epidemiology of Diabetes Interventions and Complications cohort.

Objective

To examine the long-term effects of type 1 diabetes treatment, metabolic control, and complications on health-related quality of life (HRQOL).

Research design and methods

A total of 1,441 participants, initially 13-39 years of age, were followed for an average of 23.5 years ...
S-EPMC3781542 | biostudies-literature
UnknownIntensive diabetes therapy and glomerular filtration rate in type 1 diabetes.

Background

An impaired glomerular filtration rate (GFR) leads to end-stage renal disease and increases the risks of cardiovascular disease and death. Persons with type 1 diabetes are at high risk for kidney disease, but there are no interventions that have been proved to prevent impairment o...
S-EPMC3270008 | biostudies-literature
UnknownEpigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.
We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at specific loci over two different time points in people with diabetes are associated with metabolic memory, the prolonged beneficial effects of intensive vs. conventional therapy during the Diabetes Control and Comp...
S-EPMC4890596 | biostudies-literature
UnknownImpact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.

Objective

Intensive treatment (INT) of type 1 diabetes reduces the incidence of cardiovascular disease (CVD) events compared with conventional treatment (CONV), but it also results in more weight gain. Our objective was to examine whether excessive weight gain from INT of type 1 diabetes is ...
S-EPMC5711332 | biostudies-literature
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