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TranscriptomicsGene expression profiles of murine granule neuron precursors and medulloblastoma
Sonic hedgehog (Shh) signals via Gli transcription factors to stimulate proliferation of granule neuron precursor cells (GNPs) in the cerebellum. Deregulation of Shh target genes often results in unrestrained GNP proliferation and eventually medulloblastoma (MB), the most common pediatric brain mali...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-17702 | biostudies-arrayexpress
ProteomicsA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia...
3xFLAG-IPs from HEK293T cell lysates expressing 3xFLAG-bait or 3xFLAG-control. Trypsin Digestion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-09 | MSV000079100 | MassIVE
UnknownHigh dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning.
Not available
S-EPMC10799879 | biostudies-literature
GenomicsAP-1 family members act at DNA targets in conjunction with Sox9 to promote chondrocyte hypertrophy
A comprehensive analysis of Sox9 binding profiles in developing chondrocytes identified marked enrichment of an AP-1-like motif (Ohba et al. 2015). Here, we have explored the functional interplay between Sox9 and AP-1 in mammalian chondrocyte development. Among AP-1 family members, Jun and Fosl2 wer...
ORGANISM(S): Mus musculus 
2016-02-29 | E-GEOD-73372 | biostudies-arrayexpress
TranscriptomicsA Central Role for RAF-MEK-ERK Signaling in the Genesis and Maintenance of Pancreatic Ductal Adenocarcinoma.
Although KRAS mutation is a hallmark of pancreatic ductal adenocarcinoma (PDA), mutated KRAS remains an intractable pharmacological target. Consequently, an understanding of the RAS effector pathway(s) required for PDA maintenance is critical for improved strategies to treat this disease. Here we ...
ORGANISM(S): Mus musculus 
2012-07-09 | E-GEOD-30562 | biostudies-arrayexpress
UnknownA genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci.
Not available
S-EPMC9910180 | biostudies-literature
UnknownGenome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program.
Not available
S-EPMC10063168 | biostudies-literature
UnknownDifferential methylation of the TRPA1 promoter in pain sensitivity.
Not available
S-EPMC3926001 | biostudies-literature
UnknownEvaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning.
Not available
S-EPMC11267524 | biostudies-literature
UnknownExploring threats to generalisability in a large international rehabilitation trial (AVERT).
Not available
S-EPMC4550737 | biostudies-literature
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