Basic characteristics of transcription and expression of mRNA transcriptome (mRNAome) and lncRNA transcriptome (lncRNAome) in rat cortical tissue of MCAO 2 h / R 24 h model
Ischemic stroke constitutes a multifaceted neurological affliction involving diverse cell types in the brain. A lack of dynamic transcriptional and chromatin accessibility data in the post-stroke period remains a key barrier to elucidating the underlying mechanisms. We employed snRNA-seq, snATAC-seq...
We used deep sequencing technology to find out the basic characteristics of the transcription and expression of the mRNA transcriptome (mRNAome) and lncRNA transcriptome (lncRNAome) in the rat cortical tissue of MCAO 2 h / R 24 h model. Then, we used it to obtain the basic data of mRNAome and lncRNA...
Single-cell RNA sequencing profiles of cerebral cortical tissues from mice under sham operation, wild-type MCAO/R, and endothelial-specific PEAK1-knockout MCAO/R conditions
Stroke is a leading cause of mortality and long-term disability and ischemic stroke accounts for 87% of all strokes. Though timely recanalization of the occluded vessel is essential in the treatment of ischemic stroke, it is well known to cause ischemia-reperfusion (I/R) injury which result in neuro...
