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GenomicsA Steroid Receptor Coactivator Stimulator (MCB-613) Prevents Adverse Remodeling After Myocardial Infarction
A Steroid Receptor Coactivator Stimulator (MCB-613) Prevents Adverse Remodeling After Myocardial Infarction
PRJNA661664 | ENA
TranscriptomicsA Steroid Receptor Coactivator Stimulator (MCB-613) Prevents Adverse Remodeling After Myocardial Infarction
A Steroid Receptor Coactivator Stimulator (MCB-613) Prevents Adverse Remodeling After Myocardial Infarction
ORGANISM(S): Mus musculus 
2020-09-06 | GSE157542 | GEO
UnknownA steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction.
Not available
S-EPMC7733826 | biostudies-literature
GenomicsGene expression profiling of parental and EGFR inhibitor resistant EGFR-mutant NSCLC cell lines treated with MCB-613
Gene expression profiling of parental and EGFR inhibitor resistant EGFR-mutant NSCLC cell lines treated with MCB-613
PRJNA1090829 | ENA
TranscriptomicsGene expression profiling of parental and EGFR inhibitor resistant EGFR-mutant NSCLC cell lines treated with MCB-613
RNA-seq analysis in PC9, GR4, and WZR12 cells treated with DMSO or MCB-613 for 24 hours.
ORGANISM(S): Homo sapiens 
2025-12-07 | GSE262212 | GEO
OtherCRISPR screen of genes encoding protein interactors of MCB-613 in parental and EGFR inhibitor resistant EGFR-mutant NSCLC cell lines
CRISPR screen of genes encoding protein interactors of MCB-613 in PC9, GR4, and WZR12 cells
ORGANISM(S): Homo sapiens 
2025-12-07 | GSE262214 | GEO
UnknownMCB-613 exploits a collateral sensitivity in drug resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1.
Not available
S-EPMC9882253 | biostudies-literature
GenomicsCRISPR screen of genes encoding protein interactors of MCB-613 in parental and EGFR inhibitor resistant EGFR-mutant NSCLC cell lines
CRISPR screen of genes encoding protein interactors of MCB-613 in parental and EGFR inhibitor resistant EGFR-mutant NSCLC cell lines
PRJNA1090830 | ENA
ProteomicsEGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independentKEAP1 oligomerizing molecular bridge
Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells wit...
ORGANISM(S): Homo sapiens (Human) 
2025-12-07 | PXD071547 | Pride
Keap1 Mcb-613 Egfr-mutant non-small cell lung cancer 
TranscriptomicsSteroid receptor coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress
We recently discovered that steroid receptor coactivators (SRCs) SRCs-1, 2 and 3, are abundantly expressed in cardiac fibroblasts (CFs) and their activation with the SRC small molecule stimulator MCB-613 improves cardiac function and dramatically lowers pro-fibrotic signaling in CFs post-myocardial ...
ORGANISM(S): Mus musculus 
2024-10-29 | GSE246877 | GEO
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