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ProteomicsTotal protein abundances upon Mcm6 knockdown in the murine CH12 cells
Chromosomal translocations result from joining of DNA double-strand breaks (DSBs) and frequently cause cancer. Yet, the steps linking DSB formation to DSB ligation remain undeciphered. We report that DNA replication timing (RT) directly regulates lymphomagenic Myc translocations during antibody matu...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-13 | PXD034446 | Pride
Murine ch12 cells Mcm6 knockdown Protein abundance 
UnknownCrotonylation of MCM6 enhances chemotherapeutics sensitivity of breast cancer via inducing DNA replication stress.
Not available
S-EPMC11839194 | biostudies-literature
UnknownAnalysis of the prognostic and immune role of MCM6 in pan-cancer and experimental validation in lung adenocarcinoma cells.
Not available
S-EPMC12325616 | biostudies-literature
UnknownRNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liver hepatocellular carcinoma cells.
Not available
S-EPMC10829068 | biostudies-literature
UnknownMCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.
Not available
S-EPMC9516235 | biostudies-literature
UnknownGTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer.
Not available
S-EPMC7012210 | biostudies-literature
UnknownMCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression.
Not available
S-EPMC5819696 | biostudies-literature
TranscriptomicsThe knockdown of maternal glucocorticoid receptor mRNA alters embryo development in zebrafish
In zebrafish, ovulated oocytes contain both cortisol deposited from the maternal circulation and maternal mRNA for the glucocorticoid receptor (gr mRNA), which is spread as granular structures throughout the central ooplasm. At the 1-cell stage (0.2 hpf), this transcript is relocated by streamers in...
ORGANISM(S): Danio rerio 
2011-11-16 | E-GEOD-25517 | biostudies-arrayexpress
TranscriptomicsEffect of PDCD11 silencing on gene expression in MDA-MB-231 cells
We here reported that PDCD11 deletion results in G1/S arrest and inhibited proliferation and migration of MDA-MB-231 cells. To investigate how does PDCD11 regulate the malignant phenotype of cancer cells, we performed RNA-sea analysis and found that PDCD11 knockdown leads to reduced transcriptional ...
ORGANISM(S): Homo sapiens 
2025-05-14 | GSE275527 | GEO
UnknownMinichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma.
Not available
S-EPMC7388536 | biostudies-literature
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