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ProteomicsLabel-free quantitative proteomic analysis of Candida albicans wild-type (SC5314) and mcu1/mcu1 mutant
Candida albicans is a common resident of humans that colonizes multiple body sites in most healthy individuals (e.g., the gut), but can rapidly proliferate and initiate specific microbial programs to cause infections in immunocompromised hosts. However, the molecular mechanisms underlying its commen...
ORGANISM(S): Candida albicans (Yeast) 
2026-01-20 | PXD071309 | Pride
Lc-msms Tca cycle Candida albicans 
ProteomicsA single gene mutation underpins metabolic adaptation and acquisition of filamentous competence in the emerging fungal pathogen Candida auris
Filamentous cell growth is a vital property of fungal pathogens. The mechanisms of filamentation in the emerging multidrug-resistant fungal pathogen Candida auris are poorly understood. Here, we show that exposure of C. auris to glycerol triggers a rod-like filamentation-competent (RL-FC) phenotype,...
ORGANISM(S): Fungi [Candida] auris Candida 
2024-06-12 | PXD047167 | Pride
Candida auris Bcr1 Mcu1 Skin colonization Metabolic adaptation 
TranscriptomicsTargeting MUC1-C sensitizes colorectal cancer cells to BRAF inhibitor
BRAF mutant colorectal cancer has a poor prognosis and gets resistant to BRAF inhibitors quickly. This study aims to clarify the mechanism of resistance to BRAFi. We found MCU1-C is overexpressed in BRAF mutant colorectal cancer and targeting MUC1-C genetically and pharmacologically sensitized Color...
ORGANISM(S): Homo sapiens 
2022-11-30 | GSE215849 | GEO
UnknownA single gene mutation underpins metabolic adaptation and acquisition of filamentous competence in the emerging fungal pathogen Candida auris.
Not available
S-EPMC11257696 | biostudies-literature
UnknownAntifungal Mechanisms of a Chinese Herbal Medicine, Cao Huang Gui Xiang, Against Candida Species.
Not available
S-EPMC8959912 | biostudies-literature
UnknownA Comprehensive Approach to Derivatization: Elemental Composition, Biochemical, and In Silico Studies of Metformin Derivatives Containing Copper and Zinc Complexes.
Not available
S-EPMC9919699 | biostudies-literature
GenomicsTargeting MUC1-C sensitizes colorectal cancer cells to BRAF inhibitor
Targeting MUC1-C sensitizes colorectal cancer cells to BRAF inhibitor
PRJNA890903 | ENA
ProteomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
ORGANISM(S): Homo sapiens (Human) 
2026-05-20 | PXD076314 | Pride
Nitrate  sialin2  er-mitochondria contacts  calcium signaling  lipid mobilization  adipose browning 
UnknownA Mucin1 C-terminal Subunit-directed Monoclonal Antibody Targets Overexpressed Mucin1 in Breast Cancer.
Not available
S-EPMC5743461 | biostudies-literature
MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
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