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MetabolomicsTargeting secreted MDK-mediated tryptophan/kynurenine metabolism enhances DLL3 CAR T therapy for SCLC

Small cell lung cancer (SCLC) exhibits profound immunometabolic suppression that impairs antigen presentation and constrains immunotherapy efficacy. Through integrated multi-omics analyses of primary human SCLC tumors, we identified midkine (MDK) as a dominant tumor-secreted driver of immune evas...

2026-03-23 | MTBLS14116 | MetaboLights
TranscriptomicsPerturbational sequencing of patient tumors reveals midkine as an innate immune checkpoint in neuroendocrine tumors
MCC13 MDK-WT and MDK-KO tumor cells were treated with IFNb for 24 hours and underwent bulk RNAseq. There are in total 4 conditions (control + no stim, control + IFNb, MDK-KO + no stim, MDK-KO + IFNb) and each condition has 3 biological replicates (except for control + no stim condition, due to poor ...
ORGANISM(S): Homo sapiens 
2025-11-24 | E-MTAB-15926 | biostudies-arrayexpress
ProteomicsWhole proteome of MDK model mice
MDK is a heparin-binding growth factor and found to be the Aβ associated protein. AD mouse model of MDK knockout was established to provide the animal tool to investigate the effect of MDK on AD. Through proteome, we aim to study the Aβ change and identify the DE proteins by MDK knockout to know how...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD046539 | Pride
Whole proteome Mdk Mice 
ProteomicsAggregated proteome of MDK model mice
MDK is a heparin-binding growth factor and found to be the Aβ associated protein. Through aggregated proteome, we aim to identify DE proteins more associated with plaques by MDK knockout.
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD045746 | Pride
Mdk  aggregated proteome  mice 
GenomicsEffect of MDK expressing Cervical Cancer cells(MS751) conditioned media in Human LEC
Effect of MDK expressing Cervical Cancer cells(MS751) conditioned media in Human LEC
PRJNA1095975 | ENA
GenomicsEntelexis paramagnoliae strain:MDK-2023a (JH110)
Entelexis paramagnoliae strain:MDK-2023a (JH110) Genome sequencing and assembly
PRJNA305085 | ENA
UnknownTargeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins.
Not available
S-EPMC9210922 | biostudies-literature
UnknownMDK induces temozolomide resistance in glioblastoma by promoting cancer stem-like properties.
Not available
S-EPMC9641408 | biostudies-literature
UnknownTranscriptional factor specificity protein 1 (SP1) promotes the proliferation of glioma cells by up-regulating midkine (MDK).
Not available
S-EPMC4310735 | biostudies-literature
UnknownAutocrine and paracrine effects of MDK promote lymph node metastasis of cervical squamous cell carcinoma.
Not available
S-EPMC11261016 | biostudies-literature
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