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MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
UnknownTriptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells.
Not available
S-EPMC5479278 | biostudies-literature
UnknownSingle-Cell Distribution Analysis of AR Levels by High-Throughput Microscopy in Cell Models: Application for Testing Endocrine-Disrupting Chemicals.
Not available
S-EPMC7430197 | biostudies-literature
TranscriptomicsFibroblasts from genital and extragenital regions of 46,XY individuals
This dataset contains fibroblasts from different genital and extragenital regions, mostly from 46,XY individuals. Due to proven androgen receptor gene mutations, several individuals have varying degrees of undervirilization of the external genitalia ranging from complete androgen insensitivity syndr...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-6796 | biostudies-arrayexpress
TranscriptomicsHuman scrotum and labia majora samples treated with DHT and/or AZA
Human scrotum and labia majora samples treated with DHT and/or AZA A compound treatment design type is where the response to administration of a compound or chemical (including biological compounds such as hormones) is assayed. Compound Based Treatment: dihydrotestosterone (DHT), 5-aza-deoxy-cytidin...
ORGANISM(S): Homo sapiens 
2009-05-20 | E-GEOD-11847 | biostudies-arrayexpress
ProteomicsONECUT2 acts a lineage plasticity driver
Androgen receptor- (AR-) indifference is a mechanism of resistance to hormonal therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates resistance through multiple drivers associated with adenocarcinoma, stem-like and neuroendocrine (NE) variants. Direct OC2 gene targets inc...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050634 | Pride
Onecut2 Prostate cancer Interactome Lc-ms/ms 
ProteomicsProtein posttranslational modifications of Giardia histones
Diarrheal disease caused by Giardia duodenalis is highly prevalent, totalling over 200 million cases globally each year. The processes which drive parasite virulence, host immune evasion and transmission involve coordinated gene expression, which are likely post-transcriptionally regulated. Epigenet...
ORGANISM(S): Giardia intestinalis assemblage A 
2025-08-28 | PXD019949 | Pride
Methylation Giardia Histones Chromatin Acetylation Phosphorylation 
TranscriptomicsAndrogen receptor-coregulators hormone responsiveness LNCaP / GSF
The text description is: LNCaP are androgen receptor expressing prostate carcinoma cells. Genital skin fibroblasts also express the androgen receptor. Cells were either proliferating or they were G0-arrested. Treatment of cells was performed with either the androgen DHT (dihydrotestosterone), the an...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4454 | biostudies-arrayexpress
UnknownCharacterization of the CaMKKβ-AMPK signaling complex.
Not available
S-EPMC3184326 | biostudies-literature
TranscriptomicseQTL mapping in Lake Whitefish Species Pairs.
Mapping of expression quantitative trait loci (eQTL) is a powerful means for elucidating the genetic architecture of gene regulation. Yet, eQTL mapping has not been applied towards investigating the regulation architecture of genes involved in the process of population divergence, ultimately leading...
ORGANISM(S): Coregonus clupeaformis 
2008-09-01 | E-GEOD-11378 | biostudies-arrayexpress
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