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Objective: Hepatotoxicity has been reported for Emilia sonchifolia (L.) DC (Emilia sonchifolia). The plant material is typically prepared using two extraction methods for practical application: water extraction and ethanol extraction. However, our previous research only investigated its wate...

2025-10-30 | MTBLS13237 | MetaboLights

The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacteri...

2020-04-30 | MTBLS1569 | MetaboLights

BACKGROUND: Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of these conspicuous colors remains unresolved.

RESULTS: We investigate color morph-enriched Asian vine snakes...

2023-02-23 | MTBLS6927 | MetaboLights
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 These studies detail transcriptional changes induced in cancer cells by the complex of saporin (b-SO6) and the antibody fusion protein ch128.1Av...
ORGANISM(S): Homo sapiens 

Background: Polystyrene microplastics (PS-MPs) are degradation products of plastics that are prevalent in the environment. Recent studies have established a significant correlation between exposure to PS-MPs and the incidence of cardiovascular diseases (CVD). Objective: This study aims to investi...

2026-08-16 | MTBLS14514 | MetaboLights

Background: Triple-negative breast cancer (TNBC) urgently needs effective therapies due to limited targeted options and unfavorable outcomes. We investigated Trichosanthes kirilowii Maxim formula granules (TKM) using integrated network pharmacology, metabolomics, and molecular pharmacology to cla...

2026-02-15 | MTBLS13902 | MetaboLights

Gastrodia elata Blume (GE) has been widely used to treat various central and peripheral nerve diseases, and P-Hydroxybenzaldehyde (PHBA) is one of the indicative components of GE brain protection. Since the previous study of our group found that PHBA has a good effect on protecting mitoc...

2024-07-04 | MTBLS7870 | MetaboLights
Withaferin A (WA), a major chemical component of an Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in a variety of tumor cells, but its molecular mechanism remains elusive. We report that WA induces cell death selectively in high-grade prostate (PC-3 and DU-145) and tongue (...
ORGANISM(S): Homo sapiens 
Mitochondrial oxidation-induced cell death, a physiological process triggered by various cancer therapeutics to induce oxidative stress on tumours, has been challenging to investigate owing to the difficulties in generating mitochondria-specific oxidative stress and monitoring mitochondrial response...
ORGANISM(S): Homo sapiens (Human) 
2021-03-23 | PXD022163 | Pride
RNA Biological Characteristics at the Peak of Cell Death in Different Hereditary Retinal Degeneration Mutants
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