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GenomicsGenome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 1...
ORGANISM(S): Mus musculus 
2009-05-20 | E-GEOD-15896 | biostudies-arrayexpress
ProteomicsMEF2A, MEF2C, and MEF2D Interactomes in Mouse MA-10 Leydig Cells
In steroidogenic Leydig cells, MEF2A, MEF2C, and MEF2D are key regulators of genes involved in steroid hormone synthesis, reproductive function, and oxidative stress defense. Here we used TurboID proximity-mediated biotinylation to map the protein-protein interaction networks of MEF2A, MEF2C, and ME...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-11-15 | MSV000096432 | MassIVE
TranscriptomicsGene expression changes in mouse embryonic fibroblasts (MEF cells) deficient for Ing1 and Gadd45a
ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA repair. We found that ING1b and GADD45a physically and functionally interact in the epigenetic regulation of specific target genes. In order to study this interaction further, we analysed the transcri...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-43318 | biostudies-arrayexpress
TranscriptomicsmicroRNA and mRNA expression profiles of human embryonic stem cells treated with activin A
Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self-renewal and pluripotency enable hES cells having the potential to provide an unlimited suppl...
ORGANISM(S): Homo sapiens 
2010-09-10 | E-GEOD-16910 | biostudies-arrayexpress
TranscriptomicsXenopus M-phase extract treated induced pluripotent stem cells
Transfer of somatic cell nuclei to enucleated eggs or ectopic expression of specific transcription factors are two different reprogramming strategies used to generate pluripotent cells from differentiated cells. However, they are poorly efficient and other unknown factors might be required to increa...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-31691 | biostudies-arrayexpress
TranscriptomicsComparison of the gene expression profiles between MEF, MEF treated with n-Butylenephthalide (BP) 10 and 40ug/ml.
The microarray analysis was used for comparing the gene expression profiles between MEF, MEF treated with n-Butylenephthalide (BP) 10 and 40ug/ml. The total RNA extracted from MEF, MEF treated with n-Butylenephthalide (BP) 10 and 40ug/ml was used for the microarray analysis to compare the gene expre...
ORGANISM(S): Mus musculus 
2014-03-31 | E-GEOD-36289 | biostudies-arrayexpress
TranscriptomicsGene expression data from ahES cells, ES cells, MEF cells and round sperm
Haploid stem cells offer an easy-to-manipulate genetic system and therefore have great values for studies of recessive phenotypes. Here, we show that mouse androgenetic haploid ES (ahES) cell lines can be established by transferring sperm into enucleated oocyte. The ahES cells maintain haploidy and ...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-39391 | biostudies-arrayexpress
GenomicsHistone profile for wild type MEF and secondary MEF with Dox-inducible vectors for Klf4, Sox2 and Oct4 (KSO)
Histone profile for wild type MEF and secondary MEF with Dox-inducible vectors for Klf4, Sox2 and Oct4 (KSO). ChIP-Seq data for H3K4me3, H3K27me3 and H3K9me3
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-21271 | biostudies-arrayexpress
GenomicsRNA-seq analysis of MEF cells with stably overexpression of IDH2 mutation and MEF cells treated with 2-HG
RNA-seq analysis of MEF cells with stably overexpression of IDH2 mutation and MEF cells treated with 2-HG
PRJNA748020 | ENA
TranscriptomicsGenome-wide mapping of miRNAs expressed in embryonic stem cells and pluripotent stem cells generated by different reprogramming strategies
We report the miRNA profiling in MEF cells, ES cells and three Pluripotent Stem Cells obtained by three different reprogramming approaches from MEF cells based on Solexa sequencing. iPS cells are reprogrammed by four factors (OSKM) from MEF cells. NT-ESCs were established by reprogramming MEF cells ...
ORGANISM(S): Mus musculus 
2014-07-05 | E-GEOD-52950 | biostudies-arrayexpress
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