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Myocyte Enhancer Factor 2 (MEF2) proteins are involved in multiple developmental, physiological, and pathological processes in vertebrates. Protein:protein interactions underlie the plethora of biological processes impacted by MEF2A, necessitating a detailed characterization of the MEF2A interactome...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-27 | PXD050042 | Pride
We identified genes expressed in mouse skeletal muscle, during the process of muscle regeneration after injury, which are dysregulated in the absence of Mef2a expression. MEF2A is a member of the evolutionarily conserved MEF2 transcription factor family which has known roles in cardiac muscle develo...
ORGANISM(S): Mus musculus 
In steroidogenic Leydig cells, MEF2A, MEF2C, and MEF2D are key regulators of genes involved in steroid hormone synthesis, reproductive function, and oxidative stress defense. Here we used TurboID proximity-mediated biotinylation to map the protein-protein interaction networks of MEF2A, MEF2C, and ME...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-11-15 | MSV000096432 | MassIVE
The aim of the experiment was to identify genome wide binding sites for Gata4, Mef2a, Nkx2.5, Srf, p300, Pol_II, H3ac, H3K4me1 by using Chromatin Immunoprecipitation followed by microarray analysis (ChIP-chip) in HL1 cells.
ORGANISM(S): Mus musculus 
The role of MEF2A in iPSC-CMs maturation
Calcium signaling is a central regulator of cardiomyocyte growth and function. Calmodulin is a critical mediator of calcium signals. Because the amount of calmodulin within cardiomyocytes is limiting, precise regulation of calmodulin expression may be an important for regulation of calcium signaling...
ORGANISM(S): Mus musculus 
Myocyte enhancer factor 2 A was immunoprecipitated from primary cardiomyocytes then sequenced along with its binding partners by LC-MS2 with data dependent acquisition and simultaneous isobaric label based quantification.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-02-21 | PXD038574 | Pride
Loss of MEF2A induces replicative stress responses that trigger IFN production
To understand the role of MEF2A in iPSC-CMs maturation, we used MEF2A-siRNA to reduce MEF2A transcription in iPSC-CMs and then examined the changes in transcription levels
ORGANISM(S): Homo sapiens 
2023-02-03 | GSE196655 | GEO
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