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ProteomicsAcute Megakaryoblast Leukemia LC-MS/MS
Cord blood CD34 derived megakaryoblasts, cord blood CD34 derived megakaryoblasts gene modified with the CBFA2T3-GLIS2 fusion oncogene, and CBFA2T3-GLIS2 positive acute megakaryoblast leukemia patient samples underwent multiplexed mass spectrometry-based proteomic analysis.
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD048474 | Pride
Human Acute leukemia Tmt Blood Megakaryoblast 
TranscriptomicsMeg-01 cell line expression data after propionate stimulation
Platelets are produced by megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow. Increased megakaryocyte expansion across common autoimmune diseases was shown for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS)...
ORGANISM(S): Homo sapiens 
2022-05-14 | GSE202712 | GEO
UnknownThrombopoietin-independent generation of platelet-like particles from megakaryoblastic cells.
Not available
S-EPMC10728061 | biostudies-literature
UnknownCBFA2T3-GLIS2 mediates transcriptional regulation of developmental pathways through a gene regulatory network.
Not available
S-EPMC11464917 | biostudies-literature
UnknownThe OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
Not available
S-EPMC2662544 | biostudies-literature
OtherCBFA2T3-GLIS2 Mediates Transcriptional Regulation of Developmental Pathways through a Gene Regulatory Network
CBFA2T3-GLIS2 is a fusion oncogene found in pediatric acute megakaryoblastic leukemia (AMKL) that is associated with a poor prognosis. We established a model of CBFA2T3-GLIS2 driven AMKL that allows the distinction of fusion specific changes from those that reflect the megakaryoblast lineage of this...
ORGANISM(S): Homo sapiens 
2024-08-30 | GSE219269 | GEO
Unknownc-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance.
Not available
S-EPMC9561678 | biostudies-literature
UnknownA novel thrombocytopenia-4-causing CYCS gene variant decreases caspase activity: Three-generation study.
Not available
S-EPMC11637729 | biostudies-literature
GenomicsFunctional characterization of the clonal hematopoiesis and myeloproliferative neoplasm associated polymorphism rs621940 located downstream of GFI1B
Transcription factor GFI1B suppresses its own gene expression, and deregulated GFI1B expression contributes to myeloid neoplasms. The DNA polymorphism rs621940 located 8 kb downstream of GFI1B predisposes for clonal hematopoiesis and myeloproliferative neoplasms. Whether rs621940 affects GFI1B expre...
ORGANISM(S): Homo sapiens 
2022-01-02 | GSE125246 | GEO
TranscriptomicsRNA-Seq of murine megakaryocyte progenitors (MkPs) from Cdk6 knockout and Cdk6 wild-type CALR-mutant mice
This experiment was performed to elucidate the effects of CDK6 on CALR-mutant Myeloproliferative Neoplasms. VavCre CALRdel52 knockin mice were crossed with full-body Cdk6-/- mice to obtain Cdk6-/- CALRdel52 mice. Bone marrow from mice of the four genotypes Cdk6+/+ CALR+/+ (wild-type), Cdk6+/+ CALRde...
ORGANISM(S): Mus musculus 
2026-08-03 | E-MTAB-15404 | biostudies-arrayexpress
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