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ProteomicsThe RNA-binding protein ATXN2 controls cellular processes during megakaryopoiesis
Megakaryocytes accumulate mRNA during their maturation, which is required for the correct spatio-temporal production of cytoskeletal proteins, membranes and platelet-specific granules, and for the subsequent shedding of thousands of platelets per cell. Gene expression profiling identified the RNA bi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD015823 | Pride
Lc-ms Megakaryopoiesis 
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FL...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-49664 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1)...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-51337 | biostudies-arrayexpress
ProteomicsIncreased lipid transport and de novo synthesis lead to dynamic lipidome remodeling and regulation of lipid-dependent kinases during megakaryopoiesis and proplatelet formation
During megakaryopoiesis and consecutive platelet production, megakaryocytes undergo robust cellular morphological changes which are associated with the reprogramming of signaling pathways. Moreover, it can be assumed that lipid membrane composition and signaling are strongly modified. However, the k...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-22 | PXD037622 | Pride
Megakaryocytes Lipid-dependent kinases Proteomics Lipidomics Megakaryopoiesis Lc-ms/ms 
GenomicsABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity [RNA-seq Mouse]
ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity [RNA-seq Mouse]
PRJNA982157 | ENA
GenomicsABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity [RNA-seq Human]
ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity [RNA-seq Human]
PRJNA982047 | ENA
UnknownPlasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
Not available
S-EPMC11254756 | biostudies-literature
GenomicsThe RNA-binding protein ATXN2 controls cellular processes during megakaryopoiesis.
The RNA-binding protein ATXN2 controls cellular processes during megakaryopoiesis.
PRJNA543224 | ENA
UnknownABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
Not available
S-EPMC10874622 | biostudies-literature
UnknownSuppressive effect of dengue virus envelope protein domain III on megakaryopoiesis.
Not available
S-EPMC5810469 | biostudies-literature
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