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ProteomicsTranscriptomic alterations induced by physiologically relevant level of mono(2-ethylhexyl) phthalate (MEHP) in oocytes and blastocysts
Mono(2-ethylhexyl) phthalate (MEHP), the main di(2-ethylhexyl) phthalate (DEHP) metabolite, is a known reproductive toxicant. Residual levels of 20 nM MEHP have been found in follicular fluid aspirated from IVF-treated women and DEHP-treated animals. It is not yet clear whether these residual MEHP l...
ORGANISM(S): Bos taurus (Bovine) 
2019-05-09 | PXD012092 | Pride
Mehp Gene expression Phthalate Oocyte developmental competence Transcriptome 
TranscriptomicsTranscription profiling of rat testes following exposure to mono-(2-ethylhexyl) phthalate
In rodent models, phthalate exposure alters both the fetal and pubertal testis, but the resulting histopathological changes are divergent. This suggests that the underlying molecular and cellular phthalate mechanism may be age-dependent. Using genome-wide expression profiling of acutely-exposed ra...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-4514 | biostudies-arrayexpress
TranscriptomicsSingle-cell atlas of human ovarian response to phthalate exposure reveals glial cell susceptibility and disruption of adhesion and mitochondrial pathways
The study is to investigate the effects of mono(2-ethylhexyl) phthalate (MEHP) on adult human ovarian tissue at single-cell resolution.
ORGANISM(S): Homo sapiens 
2026-07-31 | E-MTAB-15922 | biostudies-arrayexpress
GenomicsRNA-seq of TM3 Leydig and TM4 Sertoli cells under MEHP exposure
RNA-seq of TM3 Leydig and TM4 Sertoli cells under MEHP exposure
PRJNA1018824 | ENA
TranscriptomicsDose response analysis of monophthalates in the murine embryonic stem cell test
Three embryotoxic phthalate monoesters, monobutyl phthalate (MBuP), monobenzyl phthalate (MBzP) and mono-(2-ethylhexyl) phthalate (MEHP) and the non-embryotoxic monomethyl phthalate (MMP) were studied for their effects on gene expression at several concentrations that did not induce cytotoxicity. 19...
ORGANISM(S): Mus musculus 
2014-04-07 | E-GEOD-53969 | biostudies-arrayexpress
ProteomicsMEHP CETSA results for targets screening
Monoethylhexyl phthalate (MEHP) is one of the main active metabolites of the plasticizer di(2-ethylhexyl) phthalate (DEHP). It has been known that MEHP has impact on lipolysis; however, its mechanism on the cellular lipid metabolism remains largely unclear. Here, we first utilized the global lipid p...
ORGANISM(S): Homo Sapiens (human) 
2021-10-16 | PXD022034 | JPOST Repository
GenomicsRNA Sequencing of PGE2 or MEHP treated human THP-1 derived macrophages transcriptomes
RNA Sequencing of PGE2 or MEHP treated human THP-1 derived macrophages transcriptomes
PRJNA667723 | ENA
TranscriptomicsAlteration of the expression and 17, 20 lyase activity of cytochrome P450 17-hydroxylase/17, 20 lyase and of the expression of other Leydig cells genes in the rat fetal testis directly exposed to Mono-ethyl hexyl phthalate in culture.
This study aimed to investigate the direct mechanism(s) of action ofMono-(Ethyl-Hexyl) phthalate (MEHP) on the rat fetal testis with particular emphasis to Leydig cell steroidogenesis, by means of an in vitro system based on culture for 3 days of fetal testes from 14.5 days post-coïtum old rats. We ...
ORGANISM(S): Rattus norvegicus 
2011-06-01 | E-GEOD-22218 | biostudies-arrayexpress
UnknownMEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis.
Not available
S-EPMC6021206 | biostudies-literature
TranscriptomicsRNA-seq of TM3 Leydig and TM4 Sertoli cells under MEHP exposure
This study was designed to investigate the toxicological effects of MEHP on TM3 Leydig and TM4 Sertoli cells.
ORGANISM(S): Mus musculus 
2024-05-25 | GSE243503 | GEO
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