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In skeletal muscle, STAT5a/b transcription factors are critical for normal postnatal growth, whole-animal glucose homeostasis, and local IGF-1 production. These observations have led us to hypothesize that STAT5a/b are critical for maintenance of normal muscle mass and function. To investigate thi...
ORGANISM(S): Mus musculus 
Five-week-old male mice (Mus musculus, ICR) were exposed to dechlorane plus for 10 days. A total of tweenty-four mice were randomly assigned to control and three DP-treated groups. Six mice were applied in every group. For control group, corn oil was given to mice by gavage daily. For three DP-treat...
ORGANISM(S): Mus musculus 
Iron is essential for all cells but is toxic in excess, so iron absorption and distribution are tightly regulated. Serum iron is bound to transferrin and primarily enters erythroid cells via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythroc...
ORGANISM(S): Mus musculus 
abundance based on sequence+MS2 intensity, Interaction consistency score: 6.2, Coverage: 12
ORGANISM(S): 3708 
2017-00-00 | 2308287461 | PAXDB
The ongoing outbreak of novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization. This disease is marked by its rapid progression from mild to severe conditions, particularly in the absence of adequate medical care. And the mortality rate o...
ORGANISM(S): Homo Sapiens 
Purpose: Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI). In order to elucidate the potential mechanisms, RNA-seq by next generation sequencing was used to identify the rat genome-wide alterations after MI and EA treatment in t...
ORGANISM(S): Rattus norvegicus 

Studies have revealed that gut microbiota dysbiosis and bile acid metabolism play pivotal roles in the pathogenesis of inflammatory bowel disease, and there exists a reciprocal interaction between gut microbiota and bile acid metabolism. S1PR2, a G protein-coupled receptor, has been demonstrated...

2025-12-19 | MTBLS13508 | MetaboLights
Retinitis pigmentosa (RP) is an irreversible and inherited retinopathy. RPGR mutations are the most common causes of this disease. It remains challenging to decipher the mechanism of RPGR mutation because of the lack of appropriate study models. The substitution of patient-specific diseased retina w...
ORGANISM(S): Homo sapiens 
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