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ProteomicsPathogenesis of dominant-negative mutant GFI1B and associated proteomic abnormalities in megakaryocytes and platelets
Dominant-negative mutations in transcription factor Growth Factor Independence-1B (GFI1B) cause a bleeding disorder characterized by a plethora of megakaryocyte and platelet abnormalities. The deregulated molecular mechanisms and pathways are unknown. Here we show that normal and mutant GFI1B inter...
ORGANISM(S): Homo sapiens (Human) 
2019-01-25 | PXD009020 | Pride
Megakaryocytes Lsd1 Bleeding disorder Lc-ms Proteomics Platelet Gfi1b 
ProteomicsMass spectrometry analysis reveals developmental differences between platelets derived from neonates and adults
It has been proposed that developmental differences exist between neonatal and adult platelets. Detailed insight therein is, however, still lacking. We have now compared the platelet protein expression profile of neonates and adults employing a label-free quantitative mass spectrometry approach. In ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD004578 | Pride
Platelet Neonate Proteome Mass spectrometry Cord blood 
UnknownObservation of liquid glass in suspensions of ellipsoidal colloids.
Not available
S-EPMC7826331 | biostudies-literature
TranscriptomicsGenetic Aberrations Relate Early and Advanced Stage Ovarian Cancer and are Associated with Survival
BACKGROUND: Because of the distinct clinical presentation of early and advanced stage ovarian cancer, we aim to clarify whether these disease entities are solely separated by time of diagnosis or whether they arise from distinct molecular events. METHODS: Sixteen early and sixteen advanced stage ova...
ORGANISM(S): Homo sapiens 
2012-08-22 | E-GEOD-24418 | biostudies-arrayexpress
UnknownFirst-in-Human Experience With a Novel Multimodality DeepOCT-NIRS Intracoronary Imaging System.
Not available
S-EPMC11308831 | biostudies-literature
UnknownOpposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA.
Not available
S-EPMC8942367 | biostudies-literature
UnknownBreslow Intermediates (Amino Enols) and Their Keto Tautomers: First Gas-Phase Characterization by IR Ion Spectroscopy.
Not available
S-EPMC7898712 | biostudies-literature
UnknownGenome mining and metabolic profiling of the rhizosphere bacterium Pseudomonas sp. SH-C52 for antimicrobial compounds.
Not available
S-EPMC4493835 | biostudies-literature
UnknownIn situ characterization of crystallization and melting of soft, thermoresponsive microgels by small-angle X-ray scattering.
Not available
S-EPMC8864529 | biostudies-literature
UnknownInflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain.
Not available
S-EPMC10694662 | biostudies-literature
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