Sort   by:  
 Page size 
ProteomicsGFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation
The transcription factor Growth Factor Independence 1B (GFI1B) recruits Lysine Specific Demethylase 1A (LSD1/KDM1A) to stimulate gene programs relevant for megakaryocyte and platelet biology. Inherited pathogenic GFI1B variants result in thrombocytopenia and bleeding propensities with varying intens...
ORGANISM(S): Homo sapiens (Human) 
2024-03-28 | PXD050401 | Pride
Human Kdm1a Crispaint Gfi1b 
TranscriptomicsOverexpression of Gfi1b in a pro-B Abelson murine leukemia virus transformed cell line
We have conducted a screen for factors that downregulate expression of the genes encoding the V(D)J recombinase (RAG1 and RAG2) during B cell development. We have identified the transcription factor Gfi1B as being one of the proteins capable of decreasing RAG transcription when overexpressed in Ab...
ORGANISM(S): Mus musculus 
2011-12-13 | E-GEOD-33709 | biostudies-arrayexpress
ProteomicsSpecific proteome changes in platelets from individuals with GATA1-, GFI1B- and RUNX1-linked bleeding disorders
Mutations in the transcription factors GATA1, GFI1B and RUNX1 (GATA Binding Factor 1, Growth Factor Independence 1B, Runt-related transcription factor 1) cause familial platelet and bleeding disorders. Mutant platelets exhibit common abnormalities including an α-granule reduction. This suggests that...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD020343 | Pride
Platelet disorders Bleeding Transcription factors Runx1 Gata1 Gfi1b 
GenomicsTranscriptomic changes induced by GFI1B variants
Transcriptomic changes induced by GFI1B variants
PRJNA1024502 | ENA
ProteomicsPathogenesis of dominant-negative mutant GFI1B and associated proteomic abnormalities in megakaryocytes and platelets
Dominant-negative mutations in transcription factor Growth Factor Independence-1B (GFI1B) cause a bleeding disorder characterized by a plethora of megakaryocyte and platelet abnormalities. The deregulated molecular mechanisms and pathways are unknown. Here we show that normal and mutant GFI1B inter...
ORGANISM(S): Homo sapiens (Human) 
2019-01-25 | PXD009020 | Pride
Megakaryocytes Lsd1 Bleeding disorder Lc-ms Proteomics Platelet Gfi1b 
GenomicsGFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation
GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation
PRJNA1023884 | ENA
UnknownDysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation.
Not available
S-EPMC8719102 | biostudies-literature
UnknownTranscription Factor GFI1B in Health and Disease.
Not available
S-EPMC5368270 | biostudies-literature
UnknownGFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation.
Not available
S-EPMC10978956 | biostudies-literature
GenomicsFunctional characterization of the clonal hematopoiesis and myeloproliferative neoplasm associated polymorphism rs621940 located downstream of GFI1B
Functional characterization of the clonal hematopoiesis and myeloproliferative neoplasm associated polymorphism rs621940 located downstream of GFI1B
PRJNA515687 | ENA
Sort   by:  
 Page size