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TranscriptomicsRegulation of endometrial bleeding by uNK cells
Uterine NK cells (uNK) play a role in the regulation of placentation but their functions in non-pregnant endometrium are not understood. We have previously reported suppression of endometrial bleeding and alteration of spiral artery morphology in women exposed to asoprisnil, a progesterone receptor...
ORGANISM(S): Homo sapiens 
2013-08-23 | E-GEOD-47577 | biostudies-arrayexpress
TranscriptomicsHsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Atrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administer...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-66724 | biostudies-arrayexpress
ProteomicsSpecific proteome changes in platelets from individuals with GATA1-, GFI1B- and RUNX1-linked bleeding disorders
Mutations in the transcription factors GATA1, GFI1B and RUNX1 (GATA Binding Factor 1, Growth Factor Independence 1B, Runt-related transcription factor 1) cause familial platelet and bleeding disorders. Mutant platelets exhibit common abnormalities including an α-granule reduction. This suggests that...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD020343 | Pride
Platelet disorders Bleeding Transcription factors Runx1 Gata1 Gfi1b 
TranscriptomicsNovel single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding
Blood from 17 patients taking enteric-coated low-dose aspirin (LDA) and with suspected bleeding from small intestine and 18 control patients taking aspirin were analyzed. Results provide insight into the risk for aspirin-induced small bowel bleeding. 35 samples; 1 array per sample.
ORGANISM(S): Homo sapiens 
2013-11-08 | E-GEOD-52155 | biostudies-arrayexpress
ProteomicsHemostatic and platelet proteins associate with bleeding grade and time-to-major bleed in hemato-oncological patients
Bleeding crises are common complications in hemato-oncological patients undergoing chemotherapy and stem cell transplantation. Platelet transfusions are frequently administered to treat and prevent bleeding events at low platelet counts. However, the association between thrombocytopenia and bleeding...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD071376 | Pride
Bleeding Hemostasis Plasma proteomics Hemato-oncological 
GenomicsSequencing of heritable Bleeding and Platelet Disorders
The BRIDGE-BPD study aims to discover new causal genes for Bleeding and Platelet Disorders (BPD) by high throughput sequencing using cluster analyses based on improved and standardized deep phenotyping of cases. BPD is one of the 13 Rare Disease projects under the NIHR BioResource Rare Diseases BRID...
EGAS00001001172 | EGA
GenomicsBleeding
As part of the Bloodomics collaboration we have several categories of pedigrees with diseases/syndromes relevant to cardiovascular diseases (CVD). One such group, is from individuals who exhibit severe bleeding with an unknown cause. Exome sequencing has been performed as part of a discovery progra...
EGAS00001000106 | EGA
TranscriptomicsTargeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects
Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disease of the hematopoietic system, which is caused by heterozygous mutations in RUNX1. FPD/AML patients have a bleeding disorder characterized by thrombocytopenia with reduced platelet numb...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-54295 | biostudies-arrayexpress
UnknownHow I approach bleeding in hospitalized patients.
Not available
S-EPMC10562531 | biostudies-literature
GenomicsPomalidomide for the Treatment of Bleeding in HHT (PATH-HHT)
Pomalidomide for the Treatment of Bleeding in HHT (PATH-HHT)
PRJNA1231602 | ENA
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