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UnknownSusceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis.
Not available
S-EPMC6902724 | biostudies-literature
TranscriptomicsmRNA expression after siRNA-mediated knock down of Enhancer of zeste homolog 2 (Ezh2) in human umbilical vein endothelial cells
mRNA expression after Ezh2 knock down was analyzed to identify genes regulated by Ezh2. Human umbilical vein endothelial cells (HUVEC) were transfected with 25 nmol/L of control small interfering RNA (siRNA) (Silencer Select Negative Control Ambion, Austin, TX) or siRNA directed against Ezh2 (s4918;...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41610 | biostudies-arrayexpress
UnknownElucidating different pattern of immunoregulation in BALB/c and C57BL/6 mice and their F1 progeny.
Not available
S-EPMC7810711 | biostudies-literature
UnknownTranscriptome response of the white-rot fungus Trametes versicolor to hybrid poplar exhibiting unique lignin chemistry.
Not available
S-EPMC11883944 | biostudies-literature
ProteomicsCigarette smoke alters the secretome of lung epithelial cells
Cigarette smoke is the most relevant risk factor for the development of lung cancer and chronic obstructive pulmonary disease. Many of its more than 4500 chemicals are highly reactive, thereby altering protein structure and function. Here, we used subcellular fractionation coupled to label-free quan...
ORGANISM(S): Homo sapiens (Human) 
2019-01-08 | PXD007180 | Pride
Lung Proteomic profiling Cigarette smoke Secretome 
ProteomicsDissecting the molecular effects of cigarette smoke on proteasome function
Proteasome dysfunction is emerging as a novel pathomechanism for the development of chronic obstructive pulmonary disease (COPD), a major leading cause of death in the world. Cigarette smoke is one of the main risk factors for COPD and has been shown to impair proteasome function in vitro and in viv...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-01-08 | PXD007148 | Pride
Cigarette smoke Proteasome 
UnknownAnalysis of Acyl Solamines in Tuber Periderm of Cultivated and Wild Potatoes Using Liquid Chromatography Coupled With Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry.
Not available
S-EPMC12450587 | biostudies-literature
ProteomicsA lysine residue at the C-terminus of MHC class I ligands correlates with low C-terminal proteasomal cleavage probability
The majority of peptides presented by MHC class I results from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases can, either alone or together with the proteasome...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044235 | Pride
Immunopeptidomics  proteasome-independent  non-canonical mhc class i ligands  hla-a*03:01  hla-a*11:01  hla-a*30:01  proteasomal cleavage probability  peptide origin  peptide processing 
TranscriptomicsComparative global transcriptomic profiling of low and high concentration of lactacystin-mediated neuronal death
Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse cortical neurons throu...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-23155 | biostudies-arrayexpress
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
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