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GenomicsSetdb1 is essential for meiotic sex chromosome inactivation in mice
Setdb1 is essential for meiotic sex chromosome inactivation in mice
PRJNA420999 | ENA
TranscriptomicsTranscription profiling of mouse germline during spermatogenesis reveals X and Y occupy a novel compartment in the post-meiotic spermatid and adopt a non-Rabl configuration
In mammals, the X and Y chromosomes are subject to meiotic sex chromosome inactivation (MSCI) during prophase I in the male germline, but their status thereafter is currently unclear. An abundance of X-linked spermatogenesis genes has spawned the view that the X must be active [1-8]. On the other ha...
ORGANISM(S): Mus musculus 
2007-12-07 | E-GEOD-4193 | biostudies-arrayexpress
GenomicsA mutagenesis screen identifies two X-autosome translocations that disrupt meiotic sex chromosome inactivation and cause male sterility in Drosophila melanogaster
Disruption of meiotic sex chromosome inactivation in Drosophila
PRJEB102479 | ENA
GenomicsActive DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation
Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation
PRJNA870643 | ENA
GenomicsNucleolar migration regulates meiotic sex chromosome inactivation via phase separation during mammalian spermatogenesis
Nucleolar migration regulates meiotic sex chromosome inactivation via phase separation during mammalian spermatogenesis
PRJNA807299 | ENA
UnknownSETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.
Not available
S-EPMC6286383 | biostudies-literature
TranscriptomicsGene expression in mouse ovary and testis
To investigate the genomic distribution of genes with sex- biased expression patterns in mice we analyzed the chromosomal distribution of genes preferentially expressed in sexually dimorphic tissues such as testis and ovary.
ORGANISM(S): Mus musculus 
2004-03-26 | E-GEOD-1138 | biostudies-arrayexpress
GenomicsArgonaute proteins orchestrate Meiotic Sex Chromosome Inactivation and timing of the spermatogenic transcriptional program [Multiome]
Argonaute proteins orchestrate Meiotic Sex Chromosome Inactivation and timing of the spermatogenic transcriptional program [Multiome]
PRJNA1469475 | ENA
TranscriptomicsSetdb1 is essential for meiotic sex chromosome inactivation in mice
Meiotic synapsis and recombination ensure correct homologous segregation and genetic diversity. Asynapsed homologues are transcriptionally inactivated by meiotic silencing, which serves a surveillance function and in males drives meiotic sex chromosome inactivation. Silencing depends on the DNA dama...
ORGANISM(S): Mus musculus 
2018-11-01 | GSE107671 | GEO
ProteomicsArgonaute proteins regulate the timing of the spermatogenic transcriptional program
Argonaute proteins are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we show that AGO3, but not AGO2, localizes to the sex chromatin of pachytene spermatocytes nuclei, where together with AGO4, it is required for full transcriptional silencing of XY-linked...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-22 | PXD059391 | Pride
Meiosis Aargonaute Non-coding rna Brg1 Meiotic sex chromosome inactivation Sex body Spermiogenesis 
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