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ProteomicsStability of the neuronal fate determinant MEIS2 is controlled by calpain2
Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are associated with various cellular functions but have so far been mainly studied in the context of disease. Their contribution to homeostasis in the healthy organism is still not well understood and their substrates have remained...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-02-08 | PXD036442 | Pride
Stem cell Protease cleavage sites Meis2 Calpain Subventricular zone Phosphoproteomics Adult neurogenesis 
Transcriptomics4C-seq indicate interactive sites with the sequence close from Meis2 promoter
We report the distribution of interactive sites with the sequence close from Meis2 promoter within the genome of mouse embryonic forebrain. We prepared the chromatin from 11 dpc embryonic forebrain and made 3C (chromosomal conformation capture) library. High-throughput sequencing applied for the 3C ...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-52281 | biostudies-arrayexpress
TranscriptomicsMEIS2 is a novel oncogenic partner in AML1-ETO positive AML [RNA-Seq mouse]
MEIS2 collaborates with AML1-ETO in inducing acute myeloid leukemia in a murine bone marrow transplantation model We employed RNA-seq to assess similarities/differences among murine leukemic bone marrow samples transduced with either AML1-ETO/Meis2, AML1-ETO9a/Meis2, or AML1-ETO9a
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-81329 | biostudies-arrayexpress
GenomicsMeis2 ChIP-seq in palate
Meis2 ChIP-seq in palate
PRJNA602084 | ENA
TranscriptomicsIdentification of gene targets of Meis2
The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Meis2, another member of the same family, shares 82% protein identities with Meis1. Our present study suggested Meis2 exerts two distinguishable effects in differentiating ES cells. ...
ORGANISM(S): Mus musculus 
2012-08-02 | E-GEOD-34541 | biostudies-arrayexpress
TranscriptomicsMEIS2 is a novel oncogenic partner in AML1-ETO positive AML [RNA-Seq human]
MEIS2 collaborates with AML1-ETO in inducing acute myeloid leukemia in a murine bone marrow transplantation model RNA-seq to evaluate consequence of MEIS2 Knock-down on the transcriptional profle of the t(8;21) positive Kasumi-1 cell line
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-81328 | biostudies-arrayexpress
GenomicsEffect of MEIS2 overexpression on HT22 cells
Effect of MEIS2 overexpression on HT22 cells
PRJNA1118290 | ENA
ProteomicsEvolution and mechanism of MEIS2-mediated forelimb specialization in bats
The genomic basis of limb adaptations in tetrapods is thought to be largely driven by changes in gene regulation. However, the mechanisms by which regulatory programs evolve are not well understood. In bats, wing membrane development has been shown to be associated with expression of the transcripti...
ORGANISM(S): Mus musculus (Mouse) Carollia perspicillata 
2026-06-10 | PXD074776 | Pride
TranscriptomicsATAC-seq experiments to define the role of MEIS transcription factors in cardiac differentiation
Open chromatin profiling (ATAC-seq) of human embryonic stem cells NKX2-5eGFP/w (https://doi.org/10.1038/nmeth.1740) and its derivative MEIS1/MEIS2 KO on day 5 and day 12 of cardiac differentiation.
ORGANISM(S): Homo sapiens 
2025-01-30 | E-MTAB-14242 | biostudies-arrayexpress
GenomicsTranscriptome of wildtype and Meis2 mutant in the developing palate
Transcriptome of wildtype and Meis2 mutant in the developing palate
PRJNA602083 | ENA
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