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ProteomicsDynamics in protein translation sustaining T cell preparedness
In response to pathogenic threats, naïve T cells rapidly transition from a quiescent to activated state, yet the underlying mechanisms are incompletely understood. Using a pulsed SILAC approach, we investigated the dynamics of mRNA translation kinetics and protein turnover in human naïve and activat...
ORGANISM(S): Homo sapiens (Human) 
2020-06-09 | PXD017159 | Pride
T cell activation T cell preparedness T cells 
TranscriptomicsType I IFN-signaling following Pneumocystis (PC)-infection and clearance in CD4 T cell-competent mice
Type I IFN-signaling suppresses an excessive IFN-{gamma} response and prevents lung damage and chronic inflammation following Pneumocystis (PC)-infection and clearance in CD4 T cell-competent mice. Type I IFN -signaling in pulmonary CD11c+ DCs and alveolar macrophages may prevent chronic inflammatio...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-18607 | biostudies-arrayexpress
TranscriptomicsCX3CR1/Fractalkine receptor expression separates memory CD8+ T cells with distinct functional profiles (RNA-seq)
Memory T cells are important for protective immunity against infectious microorganisms. Such protection is achieved by cooperative action of memory T cell populations that differ in their tissue localization and functionality. We report on the identification of the fractalkine receptor CX3CR1 as mar...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-63144 | biostudies-arrayexpress
TranscriptomicsCX3CR1/Fractalkine receptor expression separates memory CD8+ T cells with distinct functional profiles (expression)
Memory T cells are important for protective immunity against infectious microorganisms. Such protection is achieved by cooperative action of memory T cell populations that differ in their tissue localization and functionality. We report on the identification of the fractalkine receptor CX3CR1 as mar...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-63118 | biostudies-arrayexpress
ProteomicsPD-1-targeted immunotherapy in NASH-triggered liver cancer induces pro-tumorigenic environment through CD8+PD-1+ T-cells
Immunotherapy has opened hitherto unknown possibilities to treat cancer. Whereas some cancer types (e.g. melanoma) can be efficiently treated, others lack measurable positive effects (e.g. PDAC). Moreover, stratification of responders/non-responders is only possible in some cancer types (e.g. melano...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-03 | PXD017236 | Pride
Immunotherapy Cd8+pd1+ Nash 
GenomicsAn inherently bi-functional subset of Foxp3+ Treg/T-helper cells is controlled by the transcription factor Eos
At sites of inflammation, certain Foxp3+ Tregs have the ability to alter their phenotype and become pro-inflammatory helper/effector cells, without losing Foxp3 expression. We show that this functional reprogramming is controlled by the transcription factor Eos (Ikzf4), an obligate co-repressor for...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-44380 | biostudies-arrayexpress
UnknownImaging the Meissner effect in pressurized bilayer nickelate with integrated multi-parameter quantum sensor.
Not available
S-EPMC12485607 | biostudies-literature
GenomicsWidespread targeted chromatin remodeling during the initial phase of somatic cell reprogramming [RRBS]
Despite rapid progress in characterizing transcription factor-driven reprogramming of somatic cells to an induced pluripotent stem (iPS) cell state, many mechanistic questions still remain. To gain insight into the earliest events in the reprogramming process, we systematically analyzed the transcri...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-26098 | biostudies-arrayexpress
GenomicsBLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins
BLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins
EGAS00001001598 | EGA
UnknownDepth-resolved characterization of Meissner screening breakdown in surface treated niobium.
Not available
S-EPMC11401876 | biostudies-literature
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