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ProteomicsDepletion of melanin exposes Aspergillus flavus conidial surface proteins and alters the surface architecture and virulence.
A. flavus keratitis is one of the predominant fungal infections affecting the tropical parts of the world. Melanin is a virulence factor in numerous pathogenic fungi and the melanin layer maintains the cell wall structure and provides chemical and physical protection to the organism. However, the mo...
ORGANISM(S): Aspergillus flavus FRR 3643 
2024-05-23 | PXD037707 | Pride
Non-melanized conidia Melanized conidia Melanin And surface protein 
ProteomicsPhagolysosomal proteomics identifies DHN-melanin-regulated processes in activated macrophage in response to Aspergillus fumigatus conidia
Infection by the human pathogenic fungus Aspergillus fumigatus is initialized by the outgrowth of asexual spores (conidia) into the lung tissue of the immunocompromised host following an inhalation of the airborne conidia. The resident phagocytes, the alveolar macrophages are the first immune cells ...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) Mus musculus (Mouse) 
2018-03-08 | PXD006134 | Pride
Host-pathogen interactions Aspergillus fumigatus Mycology Lc-ms Phagolysosome Dhn-melanin Macrophage Proteomics 
UnknownThe fungal-specific transcription factor Vdpf influences conidia production, melanized microsclerotia formation and pathogenicity in Verticillium dahliae.
Not available
S-EPMC6638448 | biostudies-literature
TranscriptomicsThe transcription factor Amr1 induces melanin biosynthesis and suppresses virulence in Alternaria brassicicola
Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as virulence factors affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative ...
ORGANISM(S): Alternaria brassicicola 
2013-02-19 | E-GEOD-36781 | biostudies-arrayexpress
UnknownProteomics of Aspergillus fumigatus Conidia-containing Phagolysosomes Identifies Processes Governing Immune Evasion.
Not available
S-EPMC5986250 | biostudies-literature
UnknownThe pbrB gene encodes a laccase required for DHN-melanin synthesis in conidia of Talaromyces (Penicillium) marneffei.
Not available
S-EPMC4395095 | biostudies-literature
UnknownMorphological variations and adhesive distribution: a cross-species examination in Colletotrichum conidia.
Not available
S-EPMC11671520 | biostudies-literature
UnknownMelanin depletion affects Aspergillus flavus conidial surface proteins, architecture, and virulence.
Not available
S-EPMC11004046 | biostudies-literature
UnknownFlotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections.
Not available
S-EPMC10054021 | biostudies-literature
UnknownThe mosquito melanization response is implicated in defense against the entomopathogenic fungus Beauveria bassiana.
Not available
S-EPMC3499577 | biostudies-literature
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