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TranscriptomicsBET bromodomain inhibition suppresses TH17-mediated pathology
IL-17-producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation and activation results in autoimmune conditions. Using a characterized potent and selective small mole...
ORGANISM(S): Mus musculus 
2013-09-20 | E-GEOD-37270 | biostudies-arrayexpress
TranscriptomicsRegulatory T cell modulation by CBP/EP300 bromodomain inhibition [array]
Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using microarray. Expression profiling by microarray of Treg cells treated with DMSO or CBP inhibitor, and Th0 cells
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-66596 | biostudies-arrayexpress
TranscriptomicsRegulatory T cell modulation by CBP/EP300 bromodomain inhibition [RNA-seq]
Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using RNA sequencing (RNA-seq). Expression profiling by RNA-seq of Treg cells treated with DMSO or CBP inhibitor
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-70620 | biostudies-arrayexpress
GenomicsRegulatory T cell modulation by CBP/EP300 bromodomain inhibition [ChIP-seq]
Genome-wide chromatin H3K27ac, H3K18ac and H3K4me3 occupancy changes in response to CBP inhibitor treatment in Treg cells using ChIP sequencing (ChIP-seq). Expression profiling by ChIP-seq of Treg cells treated with DMSO or CBP inhibitor
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-70708 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression response to BET inhibition in two cancer cell lines
The MYC transcription factor is a master regulator of diverse cancer pathways and somatic cell reprogramming. MYC is a compelling therapeutic target that exhibits cancer-specific cellular effects. Pharmacologic inhibition of MYC function has proven challenging due to its numerous modes of forced exp...
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-29449 | biostudies-arrayexpress
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