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GenomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35854 | biostudies-arrayexpress
TranscriptomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35856 | biostudies-arrayexpress
GenomicsA biochemical basis for toggling enhancers from the active to poised state in B cells
BCL6 is crucial for B-cell activation and lymphomagenesis. We used integrative genomics to explore BCL6 mechanism in normal and malignant B-cells. Surprisingly, BCL6 assembled distinct complexes at enhancers vs. promoters. At enhancers BCL6 preferentially recruited SMRT, which mediated H3K27 deacety...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-29282 | biostudies-arrayexpress
TranscriptomicsLeukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2 hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large AML patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a specific hypermethylation si...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-GEOD-24505 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in MDS/secondary AML and de novo AML
An increasing body of work reveals aberrant hypermethylation of genes occurring in and potentially contributing to the pathogenesis of myeloid malignancies. Several of these diseases, such as myelodysplastic syndromes (MDS), are responsive to DNA methyltransferase inhibitors. In order to determine ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-17328 | biostudies-arrayexpress
TranscriptomicsDNMT3B7 disrupts embryonic development and accelerates lymphomagenesis
Cancer cells have an altered distribution of DNA methylation and express aberrant DNA methyltransferase 3B transcripts, which encode truncated proteins. To test if a truncated DNMT3B isoform disrupts DNA methylation in vivo, we constructed transgenic mice expressing DNMT3B7, a common truncated DNMT3...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21273 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in CEBPA mutant and CEBPA silenced AML
Acute Myeloid Leukemia (AML) is a heterogeneous disease from the molecular and biological standpoints, and even patients with a specific gene expression profile may present clinical and molecular heterogeneity. We studied the epigenetic profiles of a cohort of patients that shared a common gene expr...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-14417 | biostudies-arrayexpress
TranscriptomicsPromoter hypermethylation in MLL-r leukemia: biology and therapeutic targeting
MLL-r infant acute lymphoblastic leukemia (ALL) has largely unclear oncogenesis. It has been shown unrelated to copy number change or mutations in the tyrosine kinome. We therefore, explored the possible role of genome wide CpG island hypermethylation in MLL-r infant ALL. We employed the HpaII-ti...
ORGANISM(S): Homo sapiens 
2009-12-29 | E-GEOD-19671 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation profiling of Acute Myeloid Leukemia
We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patien...
ORGANISM(S): Homo sapiens 
2010-01-12 | E-GEOD-18700 | biostudies-arrayexpress
TranscriptomicsBCL6 ChIP on chip using a Nimblegen custom tiling array
To determine whether BCL6 binds to the certain locus we performed genomic localization studies by chromatin immunoprecipitations (ChIP) using a densely tiled custom oligonucleotide microarray covering the genomic loci of different genes. Keywords: ChIP-chip, Transcription Factor localization The ex...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-7673 | biostudies-arrayexpress
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