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TranscriptomicsComparative genomic hybridization of three Streptococcus pneumoniae strains
We performed a comparative study of the two control sample options with a Streptococcus pneumoniae microarray designed with three fully sequenced strains. We hybridized two of these strains (R6 and G54) as test samples using the third strain alone (TIGR4) or a mix of the three strains as the control...
ORGANISM(S): Streptococcus pneumoniae 
2008-04-30 | E-MEXP-1390 | biostudies-arrayexpress
UnknownClonal relationships between invasive and noninvasive Lancefield group C and G streptococci and emm-specific differences in invasiveness.
Lancefield group G and group C streptococci (GGS and GCS, respectively) are pathogens responsible for a number of life-threatening infections. A collection of 116 recent (1998 to 2004) invasive (n = 28) and noninvasive (n = 88) GGS and GCS clinical isolates from Portugal were characterized. All isol...
S-EPMC1393098 | biostudies-literature
UnknownHeterogeneity of pneumococcal phase variants in invasive human infections.

Background

Streptococcus pneumoniae can be carried asymptomatically in the nasopharynx of its human host but can also cause a wide range of infections. A role for pneumococcal phase variants in the different lifestyles of this bacterium has been suggested but no systematic survey of the colo...
S-EPMC1555587 | biostudies-literature
UnknownEvidence for rare capsular switching in Streptococcus agalactiae.
The polysaccharide capsule is a major antigenic factor in Streptococcus agalactiae (Lancefield group B streptococcus [GBS]). Previous observations suggest that exchange of capsular loci is likely to occur rather frequently in GBS, even though GBS is not known to be naturally transformable. We sought...
S-EPMC2820851 | biostudies-literature
UnknownReevaluating the serotype II capsular locus of Streptococcus agalactiae.
We report a novel sequence of the serotype II capsular locus of group B streptococcus that resolves inconsistencies among the results of various groups and the sequence in GenBank. This locus was found in diverse lineages and presents genes consistent with the complete synthesis of the type II polys...
S-EPMC2045322 | biostudies-literature
UnknownThe autolysin LytA contributes to efficient bacteriophage progeny release in Streptococcus pneumoniae.
Most bacteriophages (phages) release their progeny through the action of holins that form lesions in the cytoplasmic membrane and lysins that degrade the bacterial peptidoglycan. Although the function of each protein is well established in phages infecting Streptococcus pneumoniae, the role--if any-...
S-EPMC2725628 | biostudies-literature
UnknownDNA methylase activity as a marker for the presence of a family of phage-like elements conferring efflux-mediated macrolide resistance in streptococci.
Recently, two related chimeric genetic elements (Tn1207.3 and Phi10394.4) were shown to carry the macrolide efflux gene mef in Streptococcus pyogenes (group A streptococci [GAS]). The dissemination of elements belonging to the Tn1207.3/Phi10394.4 family in recent isolates of GAS, Streptococcus dysga...
S-EPMC1635188 | biostudies-literature
UnknownPherotype influences biofilm growth and recombination in Streptococcus pneumoniae.
In Streptococcus pneumoniae the competence-stimulating peptide (CSP), encoded by the comC gene, controls competence development and influences biofilm growth. We explored the influence of pherotype, defined by the two major comC allelic variants (comC1 and comC2), on biofilm development and recombin...
S-EPMC3960169 | biostudies-literature
UnknownConsequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections.
To evaluate the importance of covRS and ropB mutations in invasive disease caused by Group A Streptococci (GAS), we determined the sequence of the covRS and ropB genes of 191 isolates from invasive infections and pharyngitis, comprising a diverse set of emm types and multilocus sequence types. The p...
S-EPMC4502508 | biostudies-literature
UnknownOptimal control and analysis of two-color genomotyping experiments using bacterial multistrain arrays.

Background

Microarray comparative genomic hybridization (aCGH) evaluates the distribution of genes of sequenced bacterial strains among unsequenced strains of the same or related species. As genomic sequences from multiple strains of the same species become available, multistrain microarrays...
S-EPMC2410139 | biostudies-literature
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